Detailed information of TA system TA274877

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3723486..3723918
• Replicon: chromosome
• Accession: NZ_CP120349
• Organism: Salmonella enterica subsp. enterica serovar Muenchen strain PS_Mu_1_2021

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: E8XIW0
• Locus tag: P1830_RS18480
• Protein ID: WP_000994224.1
• Coordinates: 3723643..3723918 (+)
• Length: 92 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3723486..3723908 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
P1830_RS18445	3719083..3719820	-	738	WP_023197904.1	pili assembly chaperone SafB	-
P1830_RS18450	3719897..3720394	-	498	WP_000789570.1	hypothetical protein	-
P1830_RS18455	3720527..3720688	-	162	WP_277623256.1	hypothetical protein	-
P1830_RS18460	3720681..3721022	-	342	WP_277623257.1	hypothetical protein	-
P1830_RS18465	3721791..3722492	-	702	Protein_3615	integrase core domain-containing protein	-
P1830_RS18470	3722545..3722793	+	249	WP_077906239.1	SymE family type I addiction module toxin	-
P1830_RS18475	3722925..3723203	-	279	WP_077906242.1	hypothetical protein	-
-	3723486..3723908	-	423	-	-	Antitoxin
P1830_RS18480	3723643..3723918	+	276	WP_000994224.1	SymE family type I addiction module toxin	Toxin
P1830_RS18485	3723971..3724381	-	411	WP_001286802.1	immunity 26/phosphotriesterase HocA family protein	-
P1830_RS18490	3724900..3725346	-	447	WP_000935097.1	protein SciX	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3712015..3746844	34829
	-	flank	IS/Tn	-	-	3721791..3722069	278

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-57)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10032.36 Da
• Isoelectric Point: 6.4704

>T274877 WP_000994224.1 NZ_CP120349:3723643-3723918 [Salmonella enterica subsp. enterica serovar Muenchen]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Nucleotide

• Length: 276 bp

Antitoxin

Nucleotide

• Length: 423 bp

>AT274877 NZ_CP120349:c3723908-3723486 [Salmonella enterica subsp. enterica serovar Muenchen]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTAACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V2JPW5

Antitoxin