Detailed information of TA system TA274823

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3723474..3723906
• Replicon: chromosome
• Accession: NZ_CP120343
• Organism: Salmonella enterica subsp. enterica serovar Paratyphi B strain PS_Mu_4_2021

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: E8XIW0
• Locus tag: P1708_RS18485
• Protein ID: WP_000994224.1
• Coordinates: 3723631..3723906 (+)
• Length: 92 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3723474..3723896 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
P1708_RS18450	3719071..3719808	-	738	WP_023197904.1	pili assembly chaperone SafB	-
P1708_RS18455	3719885..3720382	-	498	WP_000789570.1	hypothetical protein	-
P1708_RS18460	3720515..3720676	-	162	WP_277623256.1	hypothetical protein	-
P1708_RS18465	3720669..3721010	-	342	WP_277623257.1	hypothetical protein	-
P1708_RS18470	3721779..3722480	-	702	Protein_3616	integrase core domain-containing protein	-
P1708_RS18475	3722533..3722781	+	249	WP_077906239.1	SymE family type I addiction module toxin	-
P1708_RS18480	3722913..3723191	-	279	WP_077906242.1	hypothetical protein	-
-	3723474..3723896	-	423	-	-	Antitoxin
P1708_RS18485	3723631..3723906	+	276	WP_000994224.1	SymE family type I addiction module toxin	Toxin
P1708_RS18490	3723959..3724369	-	411	WP_001286802.1	immunity 26/phosphotriesterase HocA family protein	-
P1708_RS18495	3724888..3725334	-	447	WP_000935097.1	protein SciX	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3712003..3746832	34829
	-	flank	IS/Tn	-	-	3721779..3722057	278

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-57)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10032.36 Da
• Isoelectric Point: 6.4704

>T274823 WP_000994224.1 NZ_CP120343:3723631-3723906 [Salmonella enterica subsp. enterica serovar Paratyphi B]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Nucleotide

• Length: 276 bp

Antitoxin

Nucleotide

• Length: 423 bp

>AT274823 NZ_CP120343:c3723896-3723474 [Salmonella enterica subsp. enterica serovar Paratyphi B]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTAACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V2JPW5

Antitoxin