Detailed information of TA system TA274739

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3723487..3723919
• Replicon: chromosome
• Accession: NZ_CP120333
• Organism: Salmonella enterica subsp. enterica serovar Muenchen strain PS_Mu_8_2021

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: E8XIW0
• Locus tag: P1827_RS18475
• Protein ID: WP_000994224.1
• Coordinates: 3723644..3723919 (+)
• Length: 92 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3723487..3723909 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
P1827_RS18440	3719084..3719821	-	738	WP_023197904.1	pili assembly chaperone SafB	-
P1827_RS18445	3719898..3720395	-	498	WP_000789570.1	hypothetical protein	-
P1827_RS18450	3720528..3720689	-	162	WP_277623256.1	hypothetical protein	-
P1827_RS18455	3720682..3721023	-	342	WP_277623257.1	hypothetical protein	-
P1827_RS18460	3721792..3722493	-	702	Protein_3614	integrase core domain-containing protein	-
P1827_RS18465	3722546..3722794	+	249	WP_077906239.1	SymE family type I addiction module toxin	-
P1827_RS18470	3722926..3723204	-	279	WP_077906242.1	hypothetical protein	-
-	3723487..3723909	-	423	-	-	Antitoxin
P1827_RS18475	3723644..3723919	+	276	WP_000994224.1	SymE family type I addiction module toxin	Toxin
P1827_RS18480	3723972..3724382	-	411	WP_001286802.1	immunity 26/phosphotriesterase HocA family protein	-
P1827_RS18485	3724901..3725347	-	447	WP_000935097.1	protein SciX	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3712016..3746845	34829
	-	flank	IS/Tn	-	-	3721792..3722070	278

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-57)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10032.36 Da
• Isoelectric Point: 6.4704

>T274739 WP_000994224.1 NZ_CP120333:3723644-3723919 [Salmonella enterica subsp. enterica serovar Muenchen]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Nucleotide

• Length: 276 bp

Antitoxin

Nucleotide

• Length: 423 bp

>AT274739 NZ_CP120333:c3723909-3723487 [Salmonella enterica subsp. enterica serovar Muenchen]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTAACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V2JPW5

Antitoxin