Detailed information of TA system TA274687

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 1598662..1599094
• Replicon: chromosome
• Accession: NZ_CP120327
• Organism: Salmonella enterica subsp. enterica serovar Muenchen strain PS_Mu_10_2021

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: E8XIW0
• Locus tag: P1825_RS07490
• Protein ID: WP_000994224.1
• Coordinates: 1598662..1598937 (-)
• Length: 92 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	1598672..1599094 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
P1825_RS07480	1597234..1597680	+	447	WP_000935097.1	protein SciX	-
P1825_RS07485	1598199..1598609	+	411	WP_001286802.1	immunity 26/phosphotriesterase HocA family protein	-
P1825_RS07490	1598662..1598937	-	276	WP_000994224.1	SymE family type I addiction module toxin	Toxin
-	1598672..1599094	+	423	-	-	Antitoxin
P1825_RS07495	1599377..1599655	+	279	WP_077906242.1	hypothetical protein	-
P1825_RS07500	1599787..1600035	-	249	WP_077906239.1	SymE family type I addiction module toxin	-
P1825_RS07505	1600088..1600789	+	702	Protein_1450	integrase core domain-containing protein	-
P1825_RS07510	1601558..1601899	+	342	WP_277623257.1	hypothetical protein	-
P1825_RS07515	1601892..1602053	+	162	WP_277623256.1	hypothetical protein	-
P1825_RS07520	1602186..1602683	+	498	WP_000789570.1	hypothetical protein	-
P1825_RS07525	1602760..1603497	+	738	WP_023197904.1	pili assembly chaperone SafB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1577225..1611318	34093
	-	flank	IS/Tn	-	-	1600511..1600789	278

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-57)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10032.36 Da
• Isoelectric Point: 6.4704

>T274687 WP_000994224.1 NZ_CP120327:c1598937-1598662 [Salmonella enterica subsp. enterica serovar Muenchen]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Nucleotide

• Length: 276 bp

Antitoxin

Nucleotide

• Length: 423 bp

>AT274687 NZ_CP120327:1598672-1599094 [Salmonella enterica subsp. enterica serovar Muenchen]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTAACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V2JPW5

Antitoxin