Detailed information of TA system TA274492

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 909021..909435
• Replicon: chromosome
• Accession: NZ_CP119980
• Organism: Salmonella enterica strain CRIN525628

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A5I5SV33
• Locus tag: P2V98_RS04245
• Protein ID: WP_023243487.1
• Coordinates: 909021..909278 (-)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	909103..909435 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
P2V98_RS04240	908610..908954	+	345	WP_023218822.1	hypothetical protein	-
P2V98_RS04245	909021..909278	-	258	WP_023243487.1	SymE family type I addiction module toxin	Toxin
-	909103..909435	+	333	-	-	Antitoxin
P2V98_RS04250	909612..909905	+	294	WP_039515457.1	hypothetical protein	-
P2V98_RS04255	910723..911190	+	468	WP_000828178.1	sugar tyrosine-protein kinase	-
P2V98_RS04260	911507..911785	+	279	WP_077677834.1	hypothetical protein	-
P2V98_RS04265	911852..912166	-	315	WP_023892102.1	SymE family type I addiction module toxin	-
P2V98_RS04270	912219..912920	+	702	Protein_825	integrase core domain-containing protein	-
P2V98_RS04275	913619..914182	+	564	WP_023993992.1	Saf-pilin pilus formation protein SafA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	886397..932146	45749
	-	flank	IS/Tn	-	-	912642..912920	278

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9498.73 Da
• Isoelectric Point: 6.2112

>T274492 WP_023243487.1 NZ_CP119980:c909278-909021 [Salmonella enterica]
MNASGVSVRHINSETCMTTSYSHIPSQHLKGDWQEEAGFETGRSVTVKISQGCIVLMADSNEEQKLREQLYKAEQVVKGM
RDVIV

Nucleotide

• Length: 258 bp

Antitoxin

Nucleotide

• Length: 333 bp

>AT274492 NZ_CP119980:909103-909435 [Salmonella enterica]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCTCGGCCAGCACCGGGCGGTGATGAGCAACCGGCTACC
GGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A5I5SV33

Antitoxin