Detailed information of TA system TA273827

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3544621..3545043
• Replicon: chromosome
• Accession: NZ_CP119137
• Organism: Salmonella enterica subsp. enterica serovar Goldcoast isolate Sal02792

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3V8R754
• Locus tag: P0D85_RS18345
• Protein ID: WP_023232369.1
• Coordinates: 3544768..3545043 (+)
• Length: 92 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3544621..3545033 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
P0D85_RS18310	3539882..3540376	-	495	WP_126524259.1	hypothetical protein	-
P0D85_RS18315	3541136..3541837	-	702	Protein_3337	integrase core domain-containing protein	-
P0D85_RS18320	3541890..3542204	+	315	WP_023892102.1	SymE family type I addiction module toxin	-
P0D85_RS18325	3542271..3542549	-	279	WP_077905025.1	hypothetical protein	-
P0D85_RS18330	3542865..3543332	-	468	WP_063809038.1	hypothetical protein	-
P0D85_RS18335	3543329..3543700	-	372	WP_225872841.1	hypothetical protein	-
P0D85_RS18340	3544150..3544443	-	294	WP_225872842.1	hypothetical protein	-
-	3544621..3545033	-	413	-	-	Antitoxin
P0D85_RS18345	3544768..3545043	+	276	WP_023232369.1	SymE family type I addiction module toxin	Toxin
P0D85_RS18350	3545100..3545432	-	333	WP_001750702.1	barstar family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3522050..3545432	23382
	-	flank	IS/Tn	-	-	3541136..3541414	278

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-57)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 9883.21 Da
• Isoelectric Point: 6.6996

>T273827 WP_023232369.1 NZ_CP119137:3544768-3545043 [Salmonella enterica subsp. enterica serovar Goldcoast]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWLAEAGFDTGASVTVKSSEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNDVVNGN

Nucleotide

• Length: 276 bp

Antitoxin

Nucleotide

• Length: 413 bp

>AT273827 NZ_CP119137:c3545033-3544621 [Salmonella enterica subsp. enterica serovar Goldcoast]
TTCACCACATCATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGCTCTTCACGGTCACGCTCGCCCCGGTATCAAATCCCGCTT
CTGCCAGCCAGTCGCCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATGTGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCCCCCTCTCCCCGGCCAGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V8R754

Antitoxin