Detailed information of TA system TA272622

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 1530281..1530685
• Replicon: chromosome
• Accession: NZ_CP117976
• Organism: Salmonella enterica strain B-4212

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: Q57SW9
• Locus tag: PT747_RS07050
• Protein ID: WP_000994220.1
• Coordinates: 1530281..1530538 (-)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	1530363..1530685 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PT747_RS07045	1529914..1530222	+	309	WP_001539109.1	hypothetical protein	-
PT747_RS07050	1530281..1530538	-	258	WP_000994220.1	SymE family type I addiction module toxin	Toxin
-	1530363..1530685	+	323	-	-	Antitoxin
PT747_RS07055	1531658..1531882	+	225	WP_001538166.1	hypothetical protein	-
PT747_RS07060	1531975..1532442	+	468	WP_001539113.1	sugar tyrosine-protein kinase	-
PT747_RS07065	1532760..1533038	+	279	WP_012664366.1	hypothetical protein	-
PT747_RS07070	1533105..1533419	-	315	WP_001539118.1	SymE family type I addiction module toxin	-
PT747_RS07075	1533472..1534176	+	705	Protein_1368	integrase core domain-containing protein	-
PT747_RS07080	1534926..1535438	+	513	WP_001539124.1	Saf-pilin pilus formation protein SafA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1530281..1553444	23163
	-	flank	IS/Tn	-	-	1533895..1534176	281

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9426.84 Da
• Isoelectric Point: 7.1053

>T272622 WP_000994220.1 NZ_CP117976:c1530538-1530281 [Salmonella enterica]
MNASGVSVRHINSETCITTCYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYKAEQVVKGM
RDVIV

Nucleotide

• Length: 258 bp

Antitoxin

Nucleotide

• Length: 323 bp

>AT272622 NZ_CP117976:1530363-1530685 [Salmonella enterica]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGGTGCAGGCTGGGGATTTGTGAGTAACAGGTGGTTATACAGGTTTCGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGTGAGTATGGGCGCGACATCCTGGCACTGTGCCCCCCTCTCCCCGGCCAGTGATGAGCAACCGGCTGCCGGGGCCGTAT
TTT

Structures

Toxin

• AlphaFold DB: A0A5H5BJ07

Antitoxin