Detailed information of TA system TA272409

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 4515259..4515465
• Replicon: chromosome
• Accession: NZ_CP117852
• Organism: Salmonella enterica subsp. enterica serovar Mbandaka strain SM_F28R

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3Y1TUH5
• Locus tag: PTZ66_RS22115
• Protein ID: WP_026080916.1
• Coordinates: 4515259..4515465 (+)
• Length: 69 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	4515270..4515455 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PTZ66_RS22080	4510386..4510631	+	246	WP_026080917.1	SymE family type I addiction module toxin	-
PTZ66_RS22085	4510684..4511166	-	483	WP_017442170.1	immunity 26/phosphotriesterase HocA family protein	-
PTZ66_RS22090	4511685..4512131	-	447	WP_000935097.1	protein SciX	-
PTZ66_RS22095	4512125..4513093	-	969	Protein_4307	polymorphic toxin type 47 domain-containing protein	-
PTZ66_RS22100	4513519..4513653	+	135	Protein_4308	SymE family type I addiction module toxin	-
PTZ66_RS22105	4513722..4514009	-	288	WP_017442165.1	hypothetical protein	-
PTZ66_RS22110	4514012..4515265	-	1254	Protein_4310	RHS domain-containing protein	-
PTZ66_RS22115	4515259..4515465	+	207	WP_026080916.1	SymE family type I addiction module toxin	Toxin
-	4515270..4515455	-	186	-	-	Antitoxin
PTZ66_RS22120	4515512..4515790	-	279	WP_017442162.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4493625..4537995	44370
	-	inside	Genomic island	-	-	4495308..4511166	15858

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (1-34)

Sequences

Toxin

Protein

• Length: 69 a.a.
• Molecular weight: 7592.80 Da
• Isoelectric Point: 6.4569

>T272409 WP_026080916.1 NZ_CP117852:4515259-4515465 [Salmonella enterica subsp. enterica serovar Mbandaka]
IPELHLKGDWLAEAGFETGTSVTVKISEGCLILIAETDEVRDLRKELYLVKKSMKHIKAGVNNVVNRD

Nucleotide

• Length: 207 bp

Antitoxin

Nucleotide

• Length: 186 bp

>AT272409 NZ_CP117852:c4515455-4515270 [Salmonella enterica subsp. enterica serovar Mbandaka]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCAGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCCGAGATCTTCACGGTTACGCTCGTCCCGGTCTCAAATCCCGCCT
CGGCCAGCCAGTCGCCCTTAAGATGC

Structures

Toxin

• AlphaFold DB: A0A3Y1TUH5

Antitoxin