Detailed information of TA system TA272407

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 4510210..4510631
• Replicon: chromosome
• Accession: NZ_CP117852
• Organism: Salmonella enterica subsp. enterica serovar Mbandaka strain SM_F28R

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: -
• Locus tag: PTZ66_RS22080
• Protein ID: WP_026080917.1
• Coordinates: 4510386..4510631 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	4510210..4510621 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PTZ66_RS22030	4506002..4506295	-	294	WP_129369132.1	hypothetical protein	-
PTZ66_RS22035	4506629..4506874	+	246	WP_017442176.1	hypothetical protein	-
PTZ66_RS22040	4506941..4507297	-	357	WP_017442175.1	hypothetical protein	-
PTZ66_RS22045	4507294..4507671	-	378	WP_223195355.1	HNH endonuclease	-
PTZ66_RS22050	4507876..4508454	-	579	WP_017442174.1	hypothetical protein	-
PTZ66_RS22055	4508456..4508734	-	279	WP_197398372.1	hypothetical protein	-
PTZ66_RS22060	4508755..4508907	-	153	WP_223195354.1	hypothetical protein	-
PTZ66_RS22065	4509266..4509712	-	447	WP_017442172.1	hypothetical protein	-
PTZ66_RS22070	4509709..4509990	-	282	WP_176132412.1	hypothetical protein	-
PTZ66_RS22075	4510105..4510221	-	117	Protein_4303	RHS repeat-associated core domain-containing protein	-
-	4510210..4510621	-	412	-	-	Antitoxin
PTZ66_RS22080	4510386..4510631	+	246	WP_026080917.1	SymE family type I addiction module toxin	Toxin
PTZ66_RS22085	4510684..4511166	-	483	WP_017442170.1	immunity 26/phosphotriesterase HocA family protein	-
PTZ66_RS22090	4511685..4512131	-	447	WP_000935097.1	protein SciX	-
PTZ66_RS22095	4512125..4513093	-	969	Protein_4307	polymorphic toxin type 47 domain-containing protein	-
PTZ66_RS22100	4513519..4513653	+	135	Protein_4308	SymE family type I addiction module toxin	-
PTZ66_RS22105	4513722..4514009	-	288	WP_017442165.1	hypothetical protein	-
PTZ66_RS22110	4514012..4515265	-	1254	Protein_4310	RHS domain-containing protein	-
PTZ66_RS22115	4515259..4515465	+	207	WP_026080916.1	SymE family type I addiction module toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4493625..4537995	44370
	-	inside	Genomic island	-	-	4495308..4511166	15858

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (11-47)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 8992.24 Da
• Isoelectric Point: 6.7001

>T272407 WP_026080917.1 NZ_CP117852:4510386-4510631 [Salmonella enterica subsp. enterica serovar Mbandaka]
INSKACMTTCYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHIKAGVNNVVNG
D

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 412 bp

>AT272407 NZ_CP117852:c4510621-4510210 [Salmonella enterica subsp. enterica serovar Mbandaka]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGTGGTCATGCAGGCTTTGCTGTTGATGTGG
CGGACGCTGACGCCGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAG
CTCAGGGCGAGCGAGTATGGGCGCGACATCCTGGCACTGCGCTCCCCTCTCCCCGGCCGGTGATGAGCAGCCGGCTGCCG
GGGCAGTATTTT

Structures

Antitoxin