Detailed information of TA system TA272405

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/-
• Location: 4506472..4506874
• Replicon: chromosome
• Accession: NZ_CP117852
• Organism: Salmonella enterica subsp. enterica serovar Mbandaka strain SM_F28R

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A418Z3G0
• Locus tag: PTZ66_RS22035
• Protein ID: WP_017442176.1
• Coordinates: 4506629..4506874 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	4506472..4506779 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PTZ66_RS22000	4502904..4503461	+	558	Protein_4288	ATP-binding protein	-
PTZ66_RS22005	4503529..4503687	-	159	Protein_4289	transposase	-
PTZ66_RS22010	4503740..4504054	+	315	WP_072103451.1	SymE family type I addiction module toxin	-
PTZ66_RS22015	4504121..4504399	-	279	WP_077907264.1	hypothetical protein	-
PTZ66_RS22020	4504717..4505184	-	468	WP_017442178.1	hypothetical protein	-
PTZ66_RS22025	4505181..4505552	-	372	WP_223195353.1	hypothetical protein	-
PTZ66_RS22030	4506002..4506295	-	294	WP_129369132.1	hypothetical protein	-
-	4506472..4506779	-	308	-	-	Antitoxin
PTZ66_RS22035	4506629..4506874	+	246	WP_017442176.1	hypothetical protein	Toxin
PTZ66_RS22040	4506941..4507297	-	357	WP_017442175.1	hypothetical protein	-
PTZ66_RS22045	4507294..4507671	-	378	WP_223195355.1	HNH endonuclease	-
PTZ66_RS22050	4507876..4508454	-	579	WP_017442174.1	hypothetical protein	-
PTZ66_RS22055	4508456..4508734	-	279	WP_197398372.1	hypothetical protein	-
PTZ66_RS22060	4508755..4508907	-	153	WP_223195354.1	hypothetical protein	-
PTZ66_RS22065	4509266..4509712	-	447	WP_017442172.1	hypothetical protein	-
PTZ66_RS22070	4509709..4509990	-	282	WP_176132412.1	hypothetical protein	-
PTZ66_RS22075	4510105..4510221	-	117	Protein_4303	RHS repeat-associated core domain-containing protein	-
PTZ66_RS22080	4510386..4510631	+	246	WP_026080917.1	SymE family type I addiction module toxin	-
PTZ66_RS22085	4510684..4511166	-	483	WP_017442170.1	immunity 26/phosphotriesterase HocA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4493625..4537995	44370
	-	flank	IS/Tn	-	-	4503084..4503461	377
	-	inside	Genomic island	-	-	4495308..4511166	15858

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 8761.95 Da
• Isoelectric Point: 4.3010

>T272405 WP_017442176.1 NZ_CP117852:4506629-4506874 [Salmonella enterica subsp. enterica serovar Mbandaka]
MNASGASVRHINSETCMTACYSQIPSGDCQEEAGFETGRSVTVKISDGCIVLMADGNEVQKLCEQLYKAEQVVKGMWDVI
V

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 308 bp

>AT272405 NZ_CP117852:c4506779-4506472 [Salmonella enterica subsp. enterica serovar Mbandaka]
CAATACACCCGTCCGAAATCTTCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGGCAGTCGCCGCTGGGG
ATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGGCGCCGGAGGCATTCATATTTGCTGA
CTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGCGAGTATGGGCGCGACATCATGG
CACCGCGCCTCCCTCTCCCCGGCCAGCACCGGGCGGTGATGAGCAACCGGCTGCCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A418Z3G0

Antitoxin