Detailed information of TA system TA272378

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/-
• Location: 2538194..2538596
• Replicon: chromosome
• Accession: NZ_CP117851
• Organism: Salmonella enterica subsp. enterica serovar Mbandaka strain SM_B30R

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A418Z3G0
• Locus tag: PTZ67_RS12315
• Protein ID: WP_017442176.1
• Coordinates: 2538194..2538439 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	2538289..2538596 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PTZ67_RS12265	2533902..2534384	+	483	WP_017442170.1	immunity 26/phosphotriesterase HocA family protein	-
PTZ67_RS12270	2534437..2534682	-	246	WP_026080917.1	SymE family type I addiction module toxin	-
PTZ67_RS12275	2534847..2534963	+	117	Protein_2381	RHS repeat-associated core domain-containing protein	-
PTZ67_RS12280	2535078..2535359	+	282	WP_176132412.1	hypothetical protein	-
PTZ67_RS12285	2535356..2535802	+	447	WP_017442172.1	hypothetical protein	-
PTZ67_RS12290	2536161..2536313	+	153	WP_223195354.1	hypothetical protein	-
PTZ67_RS12295	2536334..2536612	+	279	WP_197398372.1	hypothetical protein	-
PTZ67_RS12300	2536614..2537192	+	579	WP_017442174.1	hypothetical protein	-
PTZ67_RS12305	2537397..2537774	+	378	WP_223195355.1	HNH endonuclease	-
PTZ67_RS12310	2537771..2538127	+	357	WP_017442175.1	hypothetical protein	-
PTZ67_RS12315	2538194..2538439	-	246	WP_017442176.1	hypothetical protein	Toxin
-	2538289..2538596	+	308	-	-	Antitoxin
PTZ67_RS12320	2538773..2539066	+	294	WP_129369132.1	hypothetical protein	-
PTZ67_RS12325	2539516..2539887	+	372	WP_223195353.1	hypothetical protein	-
PTZ67_RS12330	2539884..2540351	+	468	WP_017442178.1	hypothetical protein	-
PTZ67_RS12335	2540669..2540947	+	279	WP_077907264.1	hypothetical protein	-
PTZ67_RS12340	2541014..2541328	-	315	WP_072103451.1	SymE family type I addiction module toxin	-
PTZ67_RS12345	2541381..2541539	+	159	Protein_2395	transposase	-
PTZ67_RS12350	2541607..2542164	-	558	Protein_2396	ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2508563..2552181	43618
	-	flank	IS/Tn	-	-	2541607..2541984	377

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 8761.95 Da
• Isoelectric Point: 4.3010

>T272378 WP_017442176.1 NZ_CP117851:c2538439-2538194 [Salmonella enterica subsp. enterica serovar Mbandaka]
MNASGASVRHINSETCMTACYSQIPSGDCQEEAGFETGRSVTVKISDGCIVLMADGNEVQKLCEQLYKAEQVVKGMWDVI
V

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 308 bp

>AT272378 NZ_CP117851:2538289-2538596 [Salmonella enterica subsp. enterica serovar Mbandaka]
CAATACACCCGTCCGAAATCTTCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGGCAGTCGCCGCTGGGG
ATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGGCGCCGGAGGCATTCATATTTGCTGA
CTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGCGAGTATGGGCGCGACATCATGG
CACCGCGCCTCCCTCTCCCCGGCCAGCACCGGGCGGTGATGAGCAACCGGCTGCCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A418Z3G0

Antitoxin