Detailed information of TA system TA272376

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 2534437..2534858
• Replicon: chromosome
• Accession: NZ_CP117851
• Organism: Salmonella enterica subsp. enterica serovar Mbandaka strain SM_B30R

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: -
• Locus tag: PTZ67_RS12270
• Protein ID: WP_026080917.1
• Coordinates: 2534437..2534682 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	2534447..2534858 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PTZ67_RS12235	2529603..2529809	-	207	WP_026080916.1	SymE family type I addiction module toxin	-
PTZ67_RS12240	2529803..2531056	+	1254	Protein_2374	RHS domain-containing protein	-
PTZ67_RS12245	2531059..2531346	+	288	WP_017442165.1	hypothetical protein	-
PTZ67_RS12250	2531415..2531549	-	135	Protein_2376	SymE family type I addiction module toxin	-
PTZ67_RS12255	2531975..2532943	+	969	Protein_2377	polymorphic toxin type 47 domain-containing protein	-
PTZ67_RS12260	2532937..2533383	+	447	WP_000935097.1	protein SciX	-
PTZ67_RS12265	2533902..2534384	+	483	WP_017442170.1	immunity 26/phosphotriesterase HocA family protein	-
PTZ67_RS12270	2534437..2534682	-	246	WP_026080917.1	SymE family type I addiction module toxin	Toxin
-	2534447..2534858	+	412	-	-	Antitoxin
PTZ67_RS12275	2534847..2534963	+	117	Protein_2381	RHS repeat-associated core domain-containing protein	-
PTZ67_RS12280	2535078..2535359	+	282	WP_176132412.1	hypothetical protein	-
PTZ67_RS12285	2535356..2535802	+	447	WP_017442172.1	hypothetical protein	-
PTZ67_RS12290	2536161..2536313	+	153	WP_223195354.1	hypothetical protein	-
PTZ67_RS12295	2536334..2536612	+	279	WP_197398372.1	hypothetical protein	-
PTZ67_RS12300	2536614..2537192	+	579	WP_017442174.1	hypothetical protein	-
PTZ67_RS12305	2537397..2537774	+	378	WP_223195355.1	HNH endonuclease	-
PTZ67_RS12310	2537771..2538127	+	357	WP_017442175.1	hypothetical protein	-
PTZ67_RS12315	2538194..2538439	-	246	WP_017442176.1	hypothetical protein	-
PTZ67_RS12320	2538773..2539066	+	294	WP_129369132.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2508563..2552181	43618

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (11-47)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 8992.24 Da
• Isoelectric Point: 6.7001

>T272376 WP_026080917.1 NZ_CP117851:c2534682-2534437 [Salmonella enterica subsp. enterica serovar Mbandaka]
INSKACMTTCYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHIKAGVNNVVNG
D

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 412 bp

>AT272376 NZ_CP117851:2534447-2534858 [Salmonella enterica subsp. enterica serovar Mbandaka]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGTGGTCATGCAGGCTTTGCTGTTGATGTGG
CGGACGCTGACGCCGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAG
CTCAGGGCGAGCGAGTATGGGCGCGACATCCTGGCACTGCGCTCCCCTCTCCCCGGCCGGTGATGAGCAGCCGGCTGCCG
GGGCAGTATTTT

Structures

Antitoxin