Detailed information of TA system TA272374

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 2529603..2529809
• Replicon: chromosome
• Accession: NZ_CP117851
• Organism: Salmonella enterica subsp. enterica serovar Mbandaka strain SM_B30R

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3Y1TUH5
• Locus tag: PTZ67_RS12235
• Protein ID: WP_026080916.1
• Coordinates: 2529603..2529809 (-)
• Length: 69 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	2529613..2529798 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PTZ67_RS12230	2529278..2529556	+	279	WP_017442162.1	hypothetical protein	-
PTZ67_RS12235	2529603..2529809	-	207	WP_026080916.1	SymE family type I addiction module toxin	Toxin
-	2529613..2529798	+	186	-	-	Antitoxin
PTZ67_RS12240	2529803..2531056	+	1254	Protein_2374	RHS domain-containing protein	-
PTZ67_RS12245	2531059..2531346	+	288	WP_017442165.1	hypothetical protein	-
PTZ67_RS12250	2531415..2531549	-	135	Protein_2376	SymE family type I addiction module toxin	-
PTZ67_RS12255	2531975..2532943	+	969	Protein_2377	polymorphic toxin type 47 domain-containing protein	-
PTZ67_RS12260	2532937..2533383	+	447	WP_000935097.1	protein SciX	-
PTZ67_RS12265	2533902..2534384	+	483	WP_017442170.1	immunity 26/phosphotriesterase HocA family protein	-
PTZ67_RS12270	2534437..2534682	-	246	WP_026080917.1	SymE family type I addiction module toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2508563..2552181	43618

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (1-34)

Sequences

Toxin

Protein

• Length: 69 a.a.
• Molecular weight: 7592.80 Da
• Isoelectric Point: 6.4569

>T272374 WP_026080916.1 NZ_CP117851:c2529809-2529603 [Salmonella enterica subsp. enterica serovar Mbandaka]
IPELHLKGDWLAEAGFETGTSVTVKISEGCLILIAETDEVRDLRKELYLVKKSMKHIKAGVNNVVNRD

Nucleotide

• Length: 207 bp

Antitoxin

Nucleotide

• Length: 186 bp

>AT272374 NZ_CP117851:2529613-2529798 [Salmonella enterica subsp. enterica serovar Mbandaka]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCAGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCCGAGATCTTCACGGTTACGCTCGTCCCGGTCTCAAATCCCGCCT
CGGCCAGCCAGTCGCCCTTAAGATGC

Structures

Toxin

• AlphaFold DB: A0A3Y1TUH5

Antitoxin