Detailed information of TA system TA272361

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 4582181..4582387
• Replicon: chromosome
• Accession: NZ_CP117850
• Organism: Salmonella enterica subsp. enterica serovar Mbandaka strain SM_F22R

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3Y1TUH5
• Locus tag: PTZ65_RS22565
• Protein ID: WP_026080916.1
• Coordinates: 4582181..4582387 (+)
• Length: 69 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	4582192..4582377 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PTZ65_RS22530	4577308..4577553	+	246	WP_026080917.1	SymE family type I addiction module toxin	-
PTZ65_RS22535	4577606..4578088	-	483	WP_017442170.1	immunity 26/phosphotriesterase HocA family protein	-
PTZ65_RS22540	4578607..4579053	-	447	WP_000935097.1	protein SciX	-
PTZ65_RS22545	4579047..4580015	-	969	Protein_4397	polymorphic toxin type 47 domain-containing protein	-
PTZ65_RS22550	4580441..4580575	+	135	Protein_4398	SymE family type I addiction module toxin	-
PTZ65_RS22555	4580644..4580931	-	288	WP_017442165.1	hypothetical protein	-
PTZ65_RS22560	4580934..4582187	-	1254	Protein_4400	RHS domain-containing protein	-
PTZ65_RS22565	4582181..4582387	+	207	WP_026080916.1	SymE family type I addiction module toxin	Toxin
-	4582192..4582377	-	186	-	-	Antitoxin
PTZ65_RS22570	4582434..4582712	-	279	WP_017442162.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4560547..4603427	42880
	-	inside	Genomic island	-	-	4560547..4604917	44370

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (1-34)

Sequences

Toxin

Protein

• Length: 69 a.a.
• Molecular weight: 7592.80 Da
• Isoelectric Point: 6.4569

>T272361 WP_026080916.1 NZ_CP117850:4582181-4582387 [Salmonella enterica subsp. enterica serovar Mbandaka]
IPELHLKGDWLAEAGFETGTSVTVKISEGCLILIAETDEVRDLRKELYLVKKSMKHIKAGVNNVVNRD

Nucleotide

• Length: 207 bp

Antitoxin

Nucleotide

• Length: 186 bp

>AT272361 NZ_CP117850:c4582377-4582192 [Salmonella enterica subsp. enterica serovar Mbandaka]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCAGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCCGAGATCTTCACGGTTACGCTCGTCCCGGTCTCAAATCCCGCCT
CGGCCAGCCAGTCGCCCTTAAGATGC

Structures

Toxin

• AlphaFold DB: A0A3Y1TUH5

Antitoxin