Detailed information of TA system TA272359

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 4577132..4577553
• Replicon: chromosome
• Accession: NZ_CP117850
• Organism: Salmonella enterica subsp. enterica serovar Mbandaka strain SM_F22R

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: -
• Locus tag: PTZ65_RS22530
• Protein ID: WP_026080917.1
• Coordinates: 4577308..4577553 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	4577132..4577543 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PTZ65_RS22480	4572924..4573217	-	294	WP_129369132.1	hypothetical protein	-
PTZ65_RS22485	4573551..4573796	+	246	WP_017442176.1	hypothetical protein	-
PTZ65_RS22490	4573863..4574219	-	357	WP_017442175.1	hypothetical protein	-
PTZ65_RS22495	4574216..4574593	-	378	WP_223195355.1	HNH endonuclease	-
PTZ65_RS22500	4574798..4575376	-	579	WP_017442174.1	hypothetical protein	-
PTZ65_RS22505	4575378..4575656	-	279	WP_197398372.1	hypothetical protein	-
PTZ65_RS22510	4575677..4575829	-	153	WP_223195354.1	hypothetical protein	-
PTZ65_RS22515	4576188..4576634	-	447	WP_017442172.1	hypothetical protein	-
PTZ65_RS22520	4576631..4576912	-	282	WP_176132412.1	hypothetical protein	-
PTZ65_RS22525	4577027..4577143	-	117	Protein_4393	RHS repeat-associated core domain-containing protein	-
-	4577132..4577543	-	412	-	-	Antitoxin
PTZ65_RS22530	4577308..4577553	+	246	WP_026080917.1	SymE family type I addiction module toxin	Toxin
PTZ65_RS22535	4577606..4578088	-	483	WP_017442170.1	immunity 26/phosphotriesterase HocA family protein	-
PTZ65_RS22540	4578607..4579053	-	447	WP_000935097.1	protein SciX	-
PTZ65_RS22545	4579047..4580015	-	969	Protein_4397	polymorphic toxin type 47 domain-containing protein	-
PTZ65_RS22550	4580441..4580575	+	135	Protein_4398	SymE family type I addiction module toxin	-
PTZ65_RS22555	4580644..4580931	-	288	WP_017442165.1	hypothetical protein	-
PTZ65_RS22560	4580934..4582187	-	1254	Protein_4400	RHS domain-containing protein	-
PTZ65_RS22565	4582181..4582387	+	207	WP_026080916.1	SymE family type I addiction module toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4560547..4603427	42880
	-	inside	Genomic island	-	-	4560547..4604917	44370

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (11-47)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 8992.24 Da
• Isoelectric Point: 6.7001

>T272359 WP_026080917.1 NZ_CP117850:4577308-4577553 [Salmonella enterica subsp. enterica serovar Mbandaka]
INSKACMTTCYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHIKAGVNNVVNG
D

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 412 bp

>AT272359 NZ_CP117850:c4577543-4577132 [Salmonella enterica subsp. enterica serovar Mbandaka]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGTGGTCATGCAGGCTTTGCTGTTGATGTGG
CGGACGCTGACGCCGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAG
CTCAGGGCGAGCGAGTATGGGCGCGACATCCTGGCACTGCGCTCCCCTCTCCCCGGCCGGTGATGAGCAGCCGGCTGCCG
GGGCAGTATTTT

Structures

Antitoxin