Detailed information of TA system TA272357

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/-
• Location: 4573394..4573796
• Replicon: chromosome
• Accession: NZ_CP117850
• Organism: Salmonella enterica subsp. enterica serovar Mbandaka strain SM_F22R

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A418Z3G0
• Locus tag: PTZ65_RS22485
• Protein ID: WP_017442176.1
• Coordinates: 4573551..4573796 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	4573394..4573701 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PTZ65_RS22450	4569826..4570383	+	558	Protein_4378	ATP-binding protein	-
PTZ65_RS22455	4570451..4570609	-	159	Protein_4379	transposase	-
PTZ65_RS22460	4570662..4570976	+	315	WP_072103451.1	SymE family type I addiction module toxin	-
PTZ65_RS22465	4571043..4571321	-	279	WP_077907264.1	hypothetical protein	-
PTZ65_RS22470	4571639..4572106	-	468	WP_017442178.1	hypothetical protein	-
PTZ65_RS22475	4572103..4572474	-	372	WP_223195353.1	hypothetical protein	-
PTZ65_RS22480	4572924..4573217	-	294	WP_129369132.1	hypothetical protein	-
-	4573394..4573701	-	308	-	-	Antitoxin
PTZ65_RS22485	4573551..4573796	+	246	WP_017442176.1	hypothetical protein	Toxin
PTZ65_RS22490	4573863..4574219	-	357	WP_017442175.1	hypothetical protein	-
PTZ65_RS22495	4574216..4574593	-	378	WP_223195355.1	HNH endonuclease	-
PTZ65_RS22500	4574798..4575376	-	579	WP_017442174.1	hypothetical protein	-
PTZ65_RS22505	4575378..4575656	-	279	WP_197398372.1	hypothetical protein	-
PTZ65_RS22510	4575677..4575829	-	153	WP_223195354.1	hypothetical protein	-
PTZ65_RS22515	4576188..4576634	-	447	WP_017442172.1	hypothetical protein	-
PTZ65_RS22520	4576631..4576912	-	282	WP_176132412.1	hypothetical protein	-
PTZ65_RS22525	4577027..4577143	-	117	Protein_4393	RHS repeat-associated core domain-containing protein	-
PTZ65_RS22530	4577308..4577553	+	246	WP_026080917.1	SymE family type I addiction module toxin	-
PTZ65_RS22535	4577606..4578088	-	483	WP_017442170.1	immunity 26/phosphotriesterase HocA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	4570006..4570383	377
	-	inside	Genomic island	-	-	4560547..4603427	42880
	-	inside	Genomic island	-	-	4560547..4604917	44370

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 8761.95 Da
• Isoelectric Point: 4.3010

>T272357 WP_017442176.1 NZ_CP117850:4573551-4573796 [Salmonella enterica subsp. enterica serovar Mbandaka]
MNASGASVRHINSETCMTACYSQIPSGDCQEEAGFETGRSVTVKISDGCIVLMADGNEVQKLCEQLYKAEQVVKGMWDVI
V

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 308 bp

>AT272357 NZ_CP117850:c4573701-4573394 [Salmonella enterica subsp. enterica serovar Mbandaka]
CAATACACCCGTCCGAAATCTTCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGGCAGTCGCCGCTGGGG
ATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGGCGCCGGAGGCATTCATATTTGCTGA
CTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGCGAGTATGGGCGCGACATCATGG
CACCGCGCCTCCCTCTCCCCGGCCAGCACCGGGCGGTGATGAGCAACCGGCTGCCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A418Z3G0

Antitoxin