Detailed information of TA system TA272050

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3573235..3573667
• Replicon: chromosome
• Accession: NZ_CP117696
• Organism: Salmonella enterica subsp. enterica serovar London strain F1

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A5H8VGI7
• Locus tag: PTQ22_RS17395
• Protein ID: WP_058805824.1
• Coordinates: 3573392..3573667 (+)
• Length: 92 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3573235..3573616 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PTQ22_RS17365	3568498..3568992	-	495	WP_187788956.1	pilus assembly protein	-
PTQ22_RS17370	3569757..3570458	-	702	Protein_3404	integrase core domain-containing protein	-
PTQ22_RS17375	3570511..3570825	+	315	WP_011233128.1	SymE family type I addiction module toxin	-
PTQ22_RS17380	3570892..3571170	-	279	WP_077905025.1	hypothetical protein	-
PTQ22_RS17385	3571486..3571953	-	468	WP_000828173.1	sugar tyrosine-protein kinase	-
PTQ22_RS17390	3572825..3573058	-	234	WP_129374720.1	hypothetical protein	-
-	3573235..3573616	-	382	-	-	Antitoxin
PTQ22_RS17395	3573392..3573667	+	276	WP_058805824.1	SymE family type I addiction module toxin	Toxin
PTQ22_RS17400	3573712..3574029	-	318	WP_129374721.1	hypothetical protein	-
PTQ22_RS17405	3573995..3575278	-	1284	Protein_3411	RHS domain-containing protein	-
PTQ22_RS17410	3575415..3575879	-	465	WP_223152163.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3563670..3601559	37889
	-	flank	IS/Tn	-	-	3569757..3570035	278

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-57)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 9901.27 Da
• Isoelectric Point: 5.0770

>T272050 WP_058805824.1 NZ_CP117696:3573392-3573667 [Salmonella enterica subsp. enterica serovar London]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWLAEAGFDTGASVTVKSSEGCLTLIAERDEVQELREELYQVKQVVKGM
KVGISGVLREV

Nucleotide

• Length: 276 bp

Antitoxin

Nucleotide

• Length: 382 bp

>AT272050 NZ_CP117696:c3573616-3573235 [Salmonella enterica subsp. enterica serovar London]
CTGTTTAACCTGATAAAGTTCCTCCCGCAGCTCCTGCACCTCGTCGCGCTCCGCAATCAGAGTCAAACACCCCTCGGAGC
TCTTCACGGTCACGCTCGCCCCGGTATCAAATCCCGCTTCTGCCAGCCAGTCGCCCTTAAGGTGCTGGCTGGGGATTTGT
GAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAAT
AAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGCGAGTATGGGCGCGACATCCTGGCACCGC
GCCTCCCTCTCCCCGGCCAGTACCGGGCGGGGATGAGCAACCGGCTACCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A5H8VGI7

Antitoxin