Detailed information of TA system TA272033

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3572594..3573026
• Replicon: chromosome
• Accession: NZ_CP117693
• Organism: Salmonella enterica subsp. enterica serovar London strain S1

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A5H8VGI7
• Locus tag: PTQ18_RS17395
• Protein ID: WP_058805824.1
• Coordinates: 3572751..3573026 (+)
• Length: 92 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3572594..3572975 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PTQ18_RS17365	3567857..3568351	-	495	WP_187788956.1	pilus assembly protein	-
PTQ18_RS17370	3569116..3569817	-	702	Protein_3402	integrase core domain-containing protein	-
PTQ18_RS17375	3569870..3570184	+	315	WP_011233128.1	SymE family type I addiction module toxin	-
PTQ18_RS17380	3570251..3570529	-	279	WP_077905025.1	hypothetical protein	-
PTQ18_RS17385	3570845..3571312	-	468	WP_000828173.1	sugar tyrosine-protein kinase	-
PTQ18_RS17390	3572184..3572417	-	234	WP_129374720.1	hypothetical protein	-
-	3572594..3572975	-	382	-	-	Antitoxin
PTQ18_RS17395	3572751..3573026	+	276	WP_058805824.1	SymE family type I addiction module toxin	Toxin
PTQ18_RS17400	3573071..3573388	-	318	WP_129374721.1	hypothetical protein	-
PTQ18_RS17405	3573354..3574637	-	1284	Protein_3409	RHS domain-containing protein	-
PTQ18_RS17410	3574774..3575238	-	465	WP_223152163.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3563029..3600918	37889
	-	flank	IS/Tn	-	-	3569116..3569394	278
	-	inside	Genomic island	-	-	3559972..3600918	40946

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-57)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 9901.27 Da
• Isoelectric Point: 5.0770

>T272033 WP_058805824.1 NZ_CP117693:3572751-3573026 [Salmonella enterica subsp. enterica serovar London]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWLAEAGFDTGASVTVKSSEGCLTLIAERDEVQELREELYQVKQVVKGM
KVGISGVLREV

Nucleotide

• Length: 276 bp

Antitoxin

Nucleotide

• Length: 382 bp

>AT272033 NZ_CP117693:c3572975-3572594 [Salmonella enterica subsp. enterica serovar London]
CTGTTTAACCTGATAAAGTTCCTCCCGCAGCTCCTGCACCTCGTCGCGCTCCGCAATCAGAGTCAAACACCCCTCGGAGC
TCTTCACGGTCACGCTCGCCCCGGTATCAAATCCCGCTTCTGCCAGCCAGTCGCCCTTAAGGTGCTGGCTGGGGATTTGT
GAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAAT
AAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGCGAGTATGGGCGCGACATCCTGGCACCGC
GCCTCCCTCTCCCCGGCCAGTACCGGGCGGGGATGAGCAACCGGCTACCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A5H8VGI7

Antitoxin