Detailed information of TA system TA271128

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3688431..3688781
• Replicon: chromosome
• Accession: NZ_CP117396
• Organism: Salmonella enterica subsp. enterica serovar Uganda strain RM016

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3X9ZUV0
• Locus tag: PQP86_RS18250
• Protein ID: WP_000994229.1
• Coordinates: 3688524..3688781 (+)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3688431..3688699 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PQP86_RS18210	3683471..3684175	-	705	Protein_3562	integrase core domain-containing protein	-
PQP86_RS18215	3684228..3684476	+	249	WP_001738030.1	SymE family type I addiction module toxin	-
PQP86_RS18220	3684608..3684886	-	279	WP_079798501.1	hypothetical protein	-
PQP86_RS18225	3684969..3685085	-	117	WP_227457392.1	hypothetical protein	-
PQP86_RS18230	3685327..3685584	+	258	WP_079798500.1	SymE family type I addiction module toxin	-
PQP86_RS18235	3685675..3686052	-	378	WP_000739707.1	Imm8 family immunity protein	-
PQP86_RS18240	3686785..3687150	-	366	WP_001231281.1	hypothetical protein	-
PQP86_RS18245	3687116..3688462	-	1347	Protein_3569	RHS repeat-associated core domain-containing protein	-
-	3688431..3688699	-	269	-	-	Antitoxin
PQP86_RS18250	3688524..3688781	+	258	WP_000994229.1	SymE family type I addiction module toxin	Toxin
PQP86_RS18255	3688845..3689183	-	339	WP_000382983.1	hypothetical protein	-
PQP86_RS18260	3689554..3690594	-	1041	Protein_3572	RHS repeat-associated core domain-containing protein	-
PQP86_RS18265	3690656..3690913	+	258	WP_000994229.1	SymE family type I addiction module toxin	-
PQP86_RS18270	3690977..3691315	-	339	WP_000382983.1	hypothetical protein	-
PQP86_RS18275	3691686..3693443	-	1758	Protein_3575	RHS repeat domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3664983..3694324	29341
	-	flank	IS/Tn	-	-	3683471..3683752	281

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9538.91 Da
• Isoelectric Point: 7.2759

>T271128 WP_000994229.1 NZ_CP117396:3688524-3688781 [Salmonella enterica subsp. enterica serovar Uganda]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFETGRGVTVKISQGCIVLMADSNEEQKLREQLYKAEQVVKGM
RDVIV

Nucleotide

• Length: 258 bp

Antitoxin

Nucleotide

• Length: 269 bp

>AT271128 NZ_CP117396:c3688699-3688431 [Salmonella enterica subsp. enterica serovar Uganda]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTCACGCCGCGCCCGGTCTCAAATCCCGCTTCTTCCAGCCA
GTCACCCTTAAGGTGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGAGCGCGACAGCCTGCACCG

Structures

Toxin

• AlphaFold DB: A0A3X9ZUV0

Antitoxin