Detailed information of TA system TA271106

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3688338..3688688
• Replicon: chromosome
• Accession: NZ_CP117394
• Organism: Salmonella enterica subsp. enterica serovar Uganda strain RM017

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3X9ZUV0
• Locus tag: PQP77_RS18260
• Protein ID: WP_000994229.1
• Coordinates: 3688431..3688688 (+)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3688338..3688606 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PQP77_RS18220	3683378..3684082	-	705	Protein_3564	integrase core domain-containing protein	-
PQP77_RS18225	3684135..3684383	+	249	WP_001738030.1	SymE family type I addiction module toxin	-
PQP77_RS18230	3684515..3684793	-	279	WP_079798501.1	hypothetical protein	-
PQP77_RS18235	3684876..3684992	-	117	WP_227457392.1	hypothetical protein	-
PQP77_RS18240	3685234..3685491	+	258	WP_079798500.1	SymE family type I addiction module toxin	-
PQP77_RS18245	3685582..3685959	-	378	WP_000739707.1	Imm8 family immunity protein	-
PQP77_RS18250	3686692..3687057	-	366	WP_001231281.1	hypothetical protein	-
PQP77_RS18255	3687023..3688369	-	1347	Protein_3571	RHS repeat-associated core domain-containing protein	-
-	3688338..3688606	-	269	-	-	Antitoxin
PQP77_RS18260	3688431..3688688	+	258	WP_000994229.1	SymE family type I addiction module toxin	Toxin
PQP77_RS18265	3688752..3689090	-	339	WP_000382983.1	hypothetical protein	-
PQP77_RS18270	3689461..3690501	-	1041	Protein_3574	RHS repeat-associated core domain-containing protein	-
PQP77_RS18275	3690563..3690820	+	258	WP_000994229.1	SymE family type I addiction module toxin	-
PQP77_RS18280	3690884..3691222	-	339	WP_000382983.1	hypothetical protein	-
PQP77_RS18285	3691593..3693350	-	1758	Protein_3577	RHS repeat domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3666573..3694231	27658
	-	flank	IS/Tn	-	-	3683378..3683659	281

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9538.91 Da
• Isoelectric Point: 7.2759

>T271106 WP_000994229.1 NZ_CP117394:3688431-3688688 [Salmonella enterica subsp. enterica serovar Uganda]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFETGRGVTVKISQGCIVLMADSNEEQKLREQLYKAEQVVKGM
RDVIV

Nucleotide

• Length: 258 bp

Antitoxin

Nucleotide

• Length: 269 bp

>AT271106 NZ_CP117394:c3688606-3688338 [Salmonella enterica subsp. enterica serovar Uganda]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTCACGCCGCGCCCGGTCTCAAATCCCGCTTCTTCCAGCCA
GTCACCCTTAAGGTGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGAGCGCGACAGCCTGCACCG

Structures

Toxin

• AlphaFold DB: A0A3X9ZUV0

Antitoxin