Detailed information of TA system TA271071

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3648917..3649267
• Replicon: chromosome
• Accession: NZ_CP117390
• Organism: Salmonella enterica subsp. enterica serovar Uganda strain RM008

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3X9ZUV0
• Locus tag: PQP88_RS17935
• Protein ID: WP_000994229.1
• Coordinates: 3649010..3649267 (+)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3648917..3649185 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PQP88_RS17895	3643957..3644661	-	705	Protein_3501	integrase core domain-containing protein	-
PQP88_RS17900	3644714..3644962	+	249	WP_001738030.1	SymE family type I addiction module toxin	-
PQP88_RS17905	3645094..3645372	-	279	WP_079798501.1	hypothetical protein	-
PQP88_RS17910	3645455..3645571	-	117	WP_227457392.1	hypothetical protein	-
PQP88_RS17915	3645813..3646070	+	258	WP_079798500.1	SymE family type I addiction module toxin	-
PQP88_RS17920	3646161..3646538	-	378	WP_000739707.1	Imm8 family immunity protein	-
PQP88_RS17925	3647271..3647636	-	366	WP_001231281.1	hypothetical protein	-
PQP88_RS17930	3647602..3648948	-	1347	Protein_3508	RHS repeat-associated core domain-containing protein	-
-	3648917..3649185	-	269	-	-	Antitoxin
PQP88_RS17935	3649010..3649267	+	258	WP_000994229.1	SymE family type I addiction module toxin	Toxin
PQP88_RS17940	3649331..3649669	-	339	WP_000382983.1	hypothetical protein	-
PQP88_RS17945	3650040..3651080	-	1041	Protein_3511	RHS repeat-associated core domain-containing protein	-
PQP88_RS17950	3651142..3651399	+	258	WP_000994229.1	SymE family type I addiction module toxin	-
PQP88_RS17955	3651463..3651801	-	339	WP_000382983.1	hypothetical protein	-
PQP88_RS17960	3652172..3653929	-	1758	Protein_3514	RHS repeat domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3625471..3654810	29339
	-	flank	IS/Tn	-	-	3643957..3644238	281

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9538.91 Da
• Isoelectric Point: 7.2759

>T271071 WP_000994229.1 NZ_CP117390:3649010-3649267 [Salmonella enterica subsp. enterica serovar Uganda]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFETGRGVTVKISQGCIVLMADSNEEQKLREQLYKAEQVVKGM
RDVIV

Nucleotide

• Length: 258 bp

Antitoxin

Nucleotide

• Length: 269 bp

>AT271071 NZ_CP117390:c3649185-3648917 [Salmonella enterica subsp. enterica serovar Uganda]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTCACGCCGCGCCCGGTCTCAAATCCCGCTTCTTCCAGCCA
GTCACCCTTAAGGTGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGAGCGCGACAGCCTGCACCG

Structures

Toxin

• AlphaFold DB: A0A3X9ZUV0

Antitoxin