Detailed information of TA system TA271069

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3645656..3646070
• Replicon: chromosome
• Accession: NZ_CP117390
• Organism: Salmonella enterica subsp. enterica serovar Uganda strain RM008

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: -
• Locus tag: PQP88_RS17915
• Protein ID: WP_079798500.1
• Coordinates: 3645813..3646070 (+)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3645656..3645988 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PQP88_RS17885	3641885..3642622	-	738	WP_001750707.1	pili assembly chaperone SafB	-
PQP88_RS17890	3642699..3643196	-	498	WP_001750706.1	Saf-pilin pilus formation protein SafA	-
PQP88_RS17895	3643957..3644661	-	705	Protein_3501	integrase core domain-containing protein	-
PQP88_RS17900	3644714..3644962	+	249	WP_001738030.1	SymE family type I addiction module toxin	-
PQP88_RS17905	3645094..3645372	-	279	WP_079798501.1	hypothetical protein	-
PQP88_RS17910	3645455..3645571	-	117	WP_227457392.1	hypothetical protein	-
-	3645656..3645988	-	333	-	-	Antitoxin
PQP88_RS17915	3645813..3646070	+	258	WP_079798500.1	SymE family type I addiction module toxin	Toxin
PQP88_RS17920	3646161..3646538	-	378	WP_000739707.1	Imm8 family immunity protein	-
PQP88_RS17925	3647271..3647636	-	366	WP_001231281.1	hypothetical protein	-
PQP88_RS17930	3647602..3648948	-	1347	Protein_3508	RHS repeat-associated core domain-containing protein	-
PQP88_RS17935	3649010..3649267	+	258	WP_000994229.1	SymE family type I addiction module toxin	-
PQP88_RS17940	3649331..3649669	-	339	WP_000382983.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3625471..3654810	29339
	-	flank	IS/Tn	-	-	3643957..3644238	281

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9547.82 Da
• Isoelectric Point: 5.0770

>T271069 WP_079798500.1 NZ_CP117390:3645813-3646070 [Salmonella enterica subsp. enterica serovar Uganda]
MNASGVSVRHINSETCMSACYSQIPSQHLKGDWQEEAGFETGRSITVKISQECIVLMADSNEEQKLREQLYKAEQVVKGM
RDVIV

Nucleotide

• Length: 258 bp

Antitoxin

Nucleotide

• Length: 333 bp

>AT271069 NZ_CP117390:c3645988-3645656 [Salmonella enterica subsp. enterica serovar Uganda]
TCCGCCATCAGCACAATACACTCCTGTGAAATCTTCACGGTGATGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGACATGCAGGTTTCGCTGTTGATATGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCAGCCGGCTGCC
GGGGCCGTATTTT

Structures

Antitoxin