Detailed information of TA system TA271049

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3688474..3688824
• Replicon: chromosome
• Accession: NZ_CP117388
• Organism: Salmonella enterica subsp. enterica serovar Uganda strain RM010

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3X9ZUV0
• Locus tag: PQQ04_RS18255
• Protein ID: WP_000994229.1
• Coordinates: 3688567..3688824 (+)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3688474..3688742 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PQQ04_RS18215	3683514..3684218	-	705	Protein_3563	integrase core domain-containing protein	-
PQQ04_RS18220	3684271..3684519	+	249	WP_001738030.1	SymE family type I addiction module toxin	-
PQQ04_RS18225	3684651..3684929	-	279	WP_079798501.1	hypothetical protein	-
PQQ04_RS18230	3685012..3685128	-	117	WP_227457392.1	hypothetical protein	-
PQQ04_RS18235	3685370..3685627	+	258	WP_079798500.1	SymE family type I addiction module toxin	-
PQQ04_RS18240	3685718..3686095	-	378	WP_000739707.1	Imm8 family immunity protein	-
PQQ04_RS18245	3686828..3687193	-	366	WP_001231281.1	hypothetical protein	-
PQQ04_RS18250	3687159..3688505	-	1347	Protein_3570	RHS repeat-associated core domain-containing protein	-
-	3688474..3688742	-	269	-	-	Antitoxin
PQQ04_RS18255	3688567..3688824	+	258	WP_000994229.1	SymE family type I addiction module toxin	Toxin
PQQ04_RS18260	3688888..3689226	-	339	WP_000382983.1	hypothetical protein	-
PQQ04_RS18265	3689597..3690637	-	1041	Protein_3573	RHS repeat-associated core domain-containing protein	-
PQQ04_RS18270	3690699..3690956	+	258	WP_000994229.1	SymE family type I addiction module toxin	-
PQQ04_RS18275	3691020..3691358	-	339	WP_000382983.1	hypothetical protein	-
PQQ04_RS18280	3691729..3693486	-	1758	Protein_3576	RHS repeat domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3665026..3694367	29341
	-	flank	IS/Tn	-	-	3683514..3683795	281

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9538.91 Da
• Isoelectric Point: 7.2759

>T271049 WP_000994229.1 NZ_CP117388:3688567-3688824 [Salmonella enterica subsp. enterica serovar Uganda]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFETGRGVTVKISQGCIVLMADSNEEQKLREQLYKAEQVVKGM
RDVIV

Nucleotide

• Length: 258 bp

Antitoxin

Nucleotide

• Length: 269 bp

>AT271049 NZ_CP117388:c3688742-3688474 [Salmonella enterica subsp. enterica serovar Uganda]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTCACGCCGCGCCCGGTCTCAAATCCCGCTTCTTCCAGCCA
GTCACCCTTAAGGTGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGAGCGCGACAGCCTGCACCG

Structures

Toxin

• AlphaFold DB: A0A3X9ZUV0

Antitoxin