Detailed information of TA system TA271025

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3684724..3685138
• Replicon: chromosome
• Accession: NZ_CP117386
• Organism: Salmonella enterica subsp. enterica serovar Uganda strain RM011

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: -
• Locus tag: PQP90_RS18245
• Protein ID: WP_079798500.1
• Coordinates: 3684881..3685138 (+)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3684724..3685056 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PQP90_RS18215	3680953..3681690	-	738	WP_001750707.1	pili assembly chaperone SafB	-
PQP90_RS18220	3681767..3682264	-	498	WP_001750706.1	Saf-pilin pilus formation protein SafA	-
PQP90_RS18225	3683025..3683729	-	705	Protein_3565	integrase core domain-containing protein	-
PQP90_RS18230	3683782..3684030	+	249	WP_001738030.1	SymE family type I addiction module toxin	-
PQP90_RS18235	3684162..3684440	-	279	WP_079798501.1	hypothetical protein	-
PQP90_RS18240	3684523..3684639	-	117	WP_227457392.1	hypothetical protein	-
-	3684724..3685056	-	333	-	-	Antitoxin
PQP90_RS18245	3684881..3685138	+	258	WP_079798500.1	SymE family type I addiction module toxin	Toxin
PQP90_RS18250	3685229..3685606	-	378	WP_000739707.1	Imm8 family immunity protein	-
PQP90_RS18255	3686339..3686704	-	366	WP_001231281.1	hypothetical protein	-
PQP90_RS18260	3686670..3688016	-	1347	Protein_3572	RHS repeat-associated core domain-containing protein	-
PQP90_RS18265	3688078..3688335	+	258	WP_000994229.1	SymE family type I addiction module toxin	-
PQP90_RS18270	3688399..3688737	-	339	WP_000382983.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3664537..3693878	29341
	-	flank	IS/Tn	-	-	3683025..3683306	281

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9547.82 Da
• Isoelectric Point: 5.0770

>T271025 WP_079798500.1 NZ_CP117386:3684881-3685138 [Salmonella enterica subsp. enterica serovar Uganda]
MNASGVSVRHINSETCMSACYSQIPSQHLKGDWQEEAGFETGRSITVKISQECIVLMADSNEEQKLREQLYKAEQVVKGM
RDVIV

Nucleotide

• Length: 258 bp

Antitoxin

Nucleotide

• Length: 333 bp

>AT271025 NZ_CP117386:c3685056-3684724 [Salmonella enterica subsp. enterica serovar Uganda]
TCCGCCATCAGCACAATACACTCCTGTGAAATCTTCACGGTGATGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGACATGCAGGTTTCGCTGTTGATATGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCAGCCGGCTGCC
GGGGCCGTATTTT

Structures

Antitoxin