Detailed information of TA system TA271005

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3688634..3688984
• Replicon: chromosome
• Accession: NZ_CP117384
• Organism: Salmonella enterica subsp. enterica serovar Uganda strain RM013

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3X9ZUV0
• Locus tag: PQP89_RS18250
• Protein ID: WP_000994229.1
• Coordinates: 3688727..3688984 (+)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3688634..3688902 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PQP89_RS18210	3683674..3684378	-	705	Protein_3562	integrase core domain-containing protein	-
PQP89_RS18215	3684431..3684679	+	249	WP_001738030.1	SymE family type I addiction module toxin	-
PQP89_RS18220	3684811..3685089	-	279	WP_079798501.1	hypothetical protein	-
PQP89_RS18225	3685172..3685288	-	117	WP_227457392.1	hypothetical protein	-
PQP89_RS18230	3685530..3685787	+	258	WP_079798500.1	SymE family type I addiction module toxin	-
PQP89_RS18235	3685878..3686255	-	378	WP_000739707.1	Imm8 family immunity protein	-
PQP89_RS18240	3686988..3687353	-	366	WP_001231281.1	hypothetical protein	-
PQP89_RS18245	3687319..3688665	-	1347	Protein_3569	RHS repeat-associated core domain-containing protein	-
-	3688634..3688902	-	269	-	-	Antitoxin
PQP89_RS18250	3688727..3688984	+	258	WP_000994229.1	SymE family type I addiction module toxin	Toxin
PQP89_RS18255	3689048..3689386	-	339	WP_000382983.1	hypothetical protein	-
PQP89_RS18260	3689757..3690797	-	1041	Protein_3572	RHS repeat-associated core domain-containing protein	-
PQP89_RS18265	3690859..3691116	+	258	WP_000994229.1	SymE family type I addiction module toxin	-
PQP89_RS18270	3691180..3691518	-	339	WP_000382983.1	hypothetical protein	-
PQP89_RS18275	3691889..3693646	-	1758	Protein_3575	RHS repeat domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3665186..3694527	29341
	-	flank	IS/Tn	-	-	3683674..3683955	281

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9538.91 Da
• Isoelectric Point: 7.2759

>T271005 WP_000994229.1 NZ_CP117384:3688727-3688984 [Salmonella enterica subsp. enterica serovar Uganda]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFETGRGVTVKISQGCIVLMADSNEEQKLREQLYKAEQVVKGM
RDVIV

Nucleotide

• Length: 258 bp

Antitoxin

Nucleotide

• Length: 269 bp

>AT271005 NZ_CP117384:c3688902-3688634 [Salmonella enterica subsp. enterica serovar Uganda]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTCACGCCGCGCCCGGTCTCAAATCCCGCTTCTTCCAGCCA
GTCACCCTTAAGGTGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGAGCGCGACAGCCTGCACCG

Structures

Toxin

• AlphaFold DB: A0A3X9ZUV0

Antitoxin