Detailed information of TA system TA270985

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3690385..3690735
• Replicon: chromosome
• Accession: NZ_CP117382
• Organism: Salmonella enterica subsp. enterica serovar Uganda strain RM018

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3X9ZUV0
• Locus tag: PQP98_RS18255
• Protein ID: WP_000994229.1
• Coordinates: 3690478..3690735 (+)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3690385..3690653 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PQP98_RS18225	3685497..3685874	-	378	WP_000739707.1	Imm8 family immunity protein	-
PQP98_RS18230	3686607..3686972	-	366	WP_001231281.1	hypothetical protein	-
PQP98_RS18235	3686938..3688284	-	1347	Protein_3567	RHS repeat-associated core domain-containing protein	-
PQP98_RS18240	3688346..3688603	+	258	WP_000994229.1	SymE family type I addiction module toxin	-
PQP98_RS18245	3688667..3689005	-	339	WP_000382983.1	hypothetical protein	-
PQP98_RS18250	3689376..3690416	-	1041	Protein_3570	RHS repeat-associated core domain-containing protein	-
-	3690385..3690653	-	269	-	-	Antitoxin
PQP98_RS18255	3690478..3690735	+	258	WP_000994229.1	SymE family type I addiction module toxin	Toxin
PQP98_RS18260	3690799..3691137	-	339	WP_000382983.1	hypothetical protein	-
PQP98_RS18265	3691508..3693265	-	1758	Protein_3573	RHS repeat domain-containing protein	-
PQP98_RS18270	3693470..3693703	+	234	WP_000035941.1	hypothetical protein	-
PQP98_RS18275	3693775..3694122	-	348	WP_000887296.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3664805..3694146	29341

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9538.91 Da
• Isoelectric Point: 7.2759

>T270985 WP_000994229.1 NZ_CP117382:3690478-3690735 [Salmonella enterica subsp. enterica serovar Uganda]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFETGRGVTVKISQGCIVLMADSNEEQKLREQLYKAEQVVKGM
RDVIV

Nucleotide

• Length: 258 bp

Antitoxin

Nucleotide

• Length: 269 bp

>AT270985 NZ_CP117382:c3690653-3690385 [Salmonella enterica subsp. enterica serovar Uganda]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTCACGCCGCGCCCGGTCTCAAATCCCGCTTCTTCCAGCCA
GTCACCCTTAAGGTGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGAGCGCGACAGCCTGCACCG

Structures

Toxin

• AlphaFold DB: A0A3X9ZUV0

Antitoxin