Detailed information of TA system TA270981

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3684992..3685406
• Replicon: chromosome
• Accession: NZ_CP117382
• Organism: Salmonella enterica subsp. enterica serovar Uganda strain RM018

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: -
• Locus tag: PQP98_RS18220
• Protein ID: WP_079798500.1
• Coordinates: 3685149..3685406 (+)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3684992..3685324 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PQP98_RS18190	3681221..3681958	-	738	WP_001750707.1	pili assembly chaperone SafB	-
PQP98_RS18195	3682035..3682532	-	498	WP_001750706.1	Saf-pilin pilus formation protein SafA	-
PQP98_RS18200	3683293..3683997	-	705	Protein_3560	integrase core domain-containing protein	-
PQP98_RS18205	3684050..3684298	+	249	WP_001738030.1	SymE family type I addiction module toxin	-
PQP98_RS18210	3684430..3684708	-	279	WP_079798501.1	hypothetical protein	-
PQP98_RS18215	3684791..3684907	-	117	WP_227457392.1	hypothetical protein	-
-	3684992..3685324	-	333	-	-	Antitoxin
PQP98_RS18220	3685149..3685406	+	258	WP_079798500.1	SymE family type I addiction module toxin	Toxin
PQP98_RS18225	3685497..3685874	-	378	WP_000739707.1	Imm8 family immunity protein	-
PQP98_RS18230	3686607..3686972	-	366	WP_001231281.1	hypothetical protein	-
PQP98_RS18235	3686938..3688284	-	1347	Protein_3567	RHS repeat-associated core domain-containing protein	-
PQP98_RS18240	3688346..3688603	+	258	WP_000994229.1	SymE family type I addiction module toxin	-
PQP98_RS18245	3688667..3689005	-	339	WP_000382983.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3664805..3694146	29341
	-	flank	IS/Tn	-	-	3683293..3683574	281

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9547.82 Da
• Isoelectric Point: 5.0770

>T270981 WP_079798500.1 NZ_CP117382:3685149-3685406 [Salmonella enterica subsp. enterica serovar Uganda]
MNASGVSVRHINSETCMSACYSQIPSQHLKGDWQEEAGFETGRSITVKISQECIVLMADSNEEQKLREQLYKAEQVVKGM
RDVIV

Nucleotide

• Length: 258 bp

Antitoxin

Nucleotide

• Length: 333 bp

>AT270981 NZ_CP117382:c3685324-3684992 [Salmonella enterica subsp. enterica serovar Uganda]
TCCGCCATCAGCACAATACACTCCTGTGAAATCTTCACGGTGATGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGACATGCAGGTTTCGCTGTTGATATGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCAGCCGGCTGCC
GGGGCCGTATTTT

Structures

Antitoxin