Detailed information of TA system TA270964

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3684096..3684528
• Replicon: chromosome
• Accession: NZ_CP117380
• Organism: Salmonella enterica subsp. enterica serovar Newport strain RM037

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A0R9NU89
• Locus tag: PQP93_RS18195
• Protein ID: WP_000994228.1
• Coordinates: 3684253..3684528 (+)
• Length: 92 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3684096..3684518 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PQP93_RS18165	3679322..3679816	-	495	WP_000800125.1	hypothetical protein	-
PQP93_RS18170	3680617..3681318	-	702	Protein_3555	integrase core domain-containing protein	-
PQP93_RS18175	3681371..3681619	+	249	WP_023165496.1	SymE family type I addiction module toxin	-
PQP93_RS18180	3681751..3682029	-	279	WP_020924058.1	hypothetical protein	-
PQP93_RS18185	3682346..3682813	-	468	WP_000828173.1	sugar tyrosine-protein kinase	-
PQP93_RS18190	3683686..3683919	-	234	WP_124084119.1	hypothetical protein	-
-	3684096..3684518	-	423	-	-	Antitoxin
PQP93_RS18195	3684253..3684528	+	276	WP_000994228.1	SymE family type I addiction module toxin	Toxin
PQP93_RS18200	3684581..3685063	-	483	WP_001286803.1	immunity 26/phosphotriesterase HocA family protein	-
PQP93_RS18205	3685582..3686028	-	447	WP_000935097.1	protein SciX	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3670801..3707860	37059
	-	flank	IS/Tn	-	-	3680617..3680895	278

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10136.51 Da
• Isoelectric Point: 7.3224

>T270964 WP_000994228.1 NZ_CP117380:3684253-3684528 [Salmonella enterica subsp. enterica serovar Newport]
MNASGVSVRHINSETCMTTSYSHIPSQHLKGDWQEEAGFETGRSVTVKISKGCLILMAETDEVRELRKELYQVKKSMKHI
KAGVNDVVNGD

Nucleotide

• Length: 276 bp

Antitoxin

Nucleotide

• Length: 423 bp

>AT270964 NZ_CP117380:c3684518-3684096 [Salmonella enterica subsp. enterica serovar Newport]
TTCACCACATCATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGCTCCCTCAC
TTCGTCCGTCTCAGCCATCAGGATCAAACATCCCTTGGAGATCTTCACGGTCACGCTGCGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGTACCGGGCGGTGATGAACA
ACCGGCTACCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A0R9NU89

Antitoxin