Detailed information of TA system TA270933

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3677432..3677864
• Replicon: chromosome
• Accession: NZ_CP117376
• Organism: Salmonella enterica subsp. enterica serovar Newport strain RM041

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A0R9NU89
• Locus tag: PQQ16_RS18135
• Protein ID: WP_000994228.1
• Coordinates: 3677589..3677864 (+)
• Length: 92 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3677432..3677854 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PQQ16_RS18105	3672658..3673152	-	495	WP_000800125.1	hypothetical protein	-
PQQ16_RS18110	3673953..3674654	-	702	Protein_3543	integrase core domain-containing protein	-
PQQ16_RS18115	3674707..3674955	+	249	WP_023165496.1	SymE family type I addiction module toxin	-
PQQ16_RS18120	3675087..3675365	-	279	WP_020924058.1	hypothetical protein	-
PQQ16_RS18125	3675682..3676149	-	468	WP_000828173.1	sugar tyrosine-protein kinase	-
PQQ16_RS18130	3677022..3677255	-	234	WP_124084119.1	hypothetical protein	-
-	3677432..3677854	-	423	-	-	Antitoxin
PQQ16_RS18135	3677589..3677864	+	276	WP_000994228.1	SymE family type I addiction module toxin	Toxin
PQQ16_RS18140	3677917..3678399	-	483	WP_001286803.1	immunity 26/phosphotriesterase HocA family protein	-
PQQ16_RS18145	3678918..3679364	-	447	WP_000935097.1	protein SciX	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3664137..3701196	37059
	-	flank	IS/Tn	-	-	3673953..3674231	278

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10136.51 Da
• Isoelectric Point: 7.3224

>T270933 WP_000994228.1 NZ_CP117376:3677589-3677864 [Salmonella enterica subsp. enterica serovar Newport]
MNASGVSVRHINSETCMTTSYSHIPSQHLKGDWQEEAGFETGRSVTVKISKGCLILMAETDEVRELRKELYQVKKSMKHI
KAGVNDVVNGD

Nucleotide

• Length: 276 bp

Antitoxin

Nucleotide

• Length: 423 bp

>AT270933 NZ_CP117376:c3677854-3677432 [Salmonella enterica subsp. enterica serovar Newport]
TTCACCACATCATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGCTCCCTCAC
TTCGTCCGTCTCAGCCATCAGGATCAAACATCCCTTGGAGATCTTCACGGTCACGCTGCGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGTACCGGGCGGTGATGAACA
ACCGGCTACCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A0R9NU89

Antitoxin