Detailed information of TA system TA270894

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3677181..3677613
• Replicon: chromosome
• Accession: NZ_CP117371
• Organism: Salmonella enterica subsp. enterica serovar Newport strain RM049

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A0R9NU89
• Locus tag: PQQ06_RS18150
• Protein ID: WP_000994228.1
• Coordinates: 3677338..3677613 (+)
• Length: 92 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3677181..3677603 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PQQ06_RS18120	3672407..3672901	-	495	WP_000800125.1	hypothetical protein	-
PQQ06_RS18125	3673702..3674403	-	702	Protein_3546	integrase core domain-containing protein	-
PQQ06_RS18130	3674456..3674704	+	249	WP_023165496.1	SymE family type I addiction module toxin	-
PQQ06_RS18135	3674836..3675114	-	279	WP_020924058.1	hypothetical protein	-
PQQ06_RS18140	3675431..3675898	-	468	WP_000828173.1	sugar tyrosine-protein kinase	-
PQQ06_RS18145	3676771..3677004	-	234	WP_124084119.1	hypothetical protein	-
-	3677181..3677603	-	423	-	-	Antitoxin
PQQ06_RS18150	3677338..3677613	+	276	WP_000994228.1	SymE family type I addiction module toxin	Toxin
PQQ06_RS18155	3677666..3678146	-	481	Protein_3552	immunity 26/phosphotriesterase HocA family protein	-
PQQ06_RS18160	3678665..3679111	-	447	WP_000935097.1	protein SciX	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3663886..3700943	37057
	-	flank	IS/Tn	-	-	3673702..3673980	278

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10136.51 Da
• Isoelectric Point: 7.3224

>T270894 WP_000994228.1 NZ_CP117371:3677338-3677613 [Salmonella enterica subsp. enterica serovar Newport]
MNASGVSVRHINSETCMTTSYSHIPSQHLKGDWQEEAGFETGRSVTVKISKGCLILMAETDEVRELRKELYQVKKSMKHI
KAGVNDVVNGD

Nucleotide

• Length: 276 bp

Antitoxin

Nucleotide

• Length: 423 bp

>AT270894 NZ_CP117371:c3677603-3677181 [Salmonella enterica subsp. enterica serovar Newport]
TTCACCACATCATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGCTCCCTCAC
TTCGTCCGTCTCAGCCATCAGGATCAAACATCCCTTGGAGATCTTCACGGTCACGCTGCGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGTACCGGGCGGTGATGAACA
ACCGGCTACCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A0R9NU89

Antitoxin