Detailed information of TA system TA270837

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3641866..3642298
• Replicon: chromosome
• Accession: NZ_CP117365
• Organism: Salmonella enterica subsp. enterica serovar Newport strain RM089

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A0R9NU89
• Locus tag: PQP78_RS17910
• Protein ID: WP_000994228.1
• Coordinates: 3642023..3642298 (+)
• Length: 92 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3641866..3642288 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PQP78_RS17880	3637092..3637586	-	495	WP_000800125.1	hypothetical protein	-
PQP78_RS17885	3638387..3639088	-	702	Protein_3498	integrase core domain-containing protein	-
PQP78_RS17890	3639141..3639389	+	249	WP_023165496.1	SymE family type I addiction module toxin	-
PQP78_RS17895	3639521..3639799	-	279	WP_020924058.1	hypothetical protein	-
PQP78_RS17900	3640116..3640583	-	468	WP_000828173.1	sugar tyrosine-protein kinase	-
PQP78_RS17905	3641456..3641689	-	234	WP_124084119.1	hypothetical protein	-
-	3641866..3642288	-	423	-	-	Antitoxin
PQP78_RS17910	3642023..3642298	+	276	WP_000994228.1	SymE family type I addiction module toxin	Toxin
PQP78_RS17915	3642351..3642833	-	483	WP_001286803.1	immunity 26/phosphotriesterase HocA family protein	-
PQP78_RS17920	3643350..3643796	-	447	WP_000935097.1	protein SciX	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3628571..3665628	37057
	-	flank	IS/Tn	-	-	3638387..3638665	278

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10136.51 Da
• Isoelectric Point: 7.3224

>T270837 WP_000994228.1 NZ_CP117365:3642023-3642298 [Salmonella enterica subsp. enterica serovar Newport]
MNASGVSVRHINSETCMTTSYSHIPSQHLKGDWQEEAGFETGRSVTVKISKGCLILMAETDEVRELRKELYQVKKSMKHI
KAGVNDVVNGD

Nucleotide

• Length: 276 bp

Antitoxin

Nucleotide

• Length: 423 bp

>AT270837 NZ_CP117365:c3642288-3641866 [Salmonella enterica subsp. enterica serovar Newport]
TTCACCACATCATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGCTCCCTCAC
TTCGTCCGTCTCAGCCATCAGGATCAAACATCCCTTGGAGATCTTCACGGTCACGCTGCGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGTACCGGGCGGTGATGAACA
ACCGGCTACCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A0R9NU89

Antitoxin