Detailed information of TA system TA270515

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3612470..3612902
• Replicon: chromosome
• Accession: NZ_CP117326
• Organism: Salmonella enterica subsp. enterica serovar Newport strain RM108

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A0R9NU89
• Locus tag: PQQ05_RS17670
• Protein ID: WP_000994228.1
• Coordinates: 3612627..3612902 (+)
• Length: 92 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3612470..3612892 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PQQ05_RS17645	3607615..3608109	-	495	WP_274895312.1	hypothetical protein	-
PQQ05_RS17650	3608992..3609693	-	702	Protein_3452	integrase core domain-containing protein	-
PQQ05_RS17655	3609746..3609994	+	249	WP_023165496.1	SymE family type I addiction module toxin	-
PQQ05_RS17660	3610126..3610404	-	279	WP_020924058.1	hypothetical protein	-
PQQ05_RS17665	3610721..3611188	-	468	WP_000828173.1	sugar tyrosine-protein kinase	-
-	3612470..3612892	-	423	-	-	Antitoxin
PQQ05_RS17670	3612627..3612902	+	276	WP_000994228.1	SymE family type I addiction module toxin	Toxin
PQQ05_RS17675	3612955..3613437	-	483	WP_001286803.1	immunity 26/phosphotriesterase HocA family protein	-
PQQ05_RS17680	3613956..3614402	-	447	WP_000935097.1	protein SciX	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3599094..3636234	37140
	-	flank	IS/Tn	-	-	3608992..3609270	278

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10136.51 Da
• Isoelectric Point: 7.3224

>T270515 WP_000994228.1 NZ_CP117326:3612627-3612902 [Salmonella enterica subsp. enterica serovar Newport]
MNASGVSVRHINSETCMTTSYSHIPSQHLKGDWQEEAGFETGRSVTVKISKGCLILMAETDEVRELRKELYQVKKSMKHI
KAGVNDVVNGD

Nucleotide

• Length: 276 bp

Antitoxin

Nucleotide

• Length: 423 bp

>AT270515 NZ_CP117326:c3612892-3612470 [Salmonella enterica subsp. enterica serovar Newport]
TTCACCACATCATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGCTCCCTCAC
TTCGTCCGTCTCAGCCATCAGGATCAAACATCCCTTGGAGATCTTCACGGTCACGCTGCGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGTACCGGGCGGTGATGAACA
ACCGGCTACCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A0R9NU89

Antitoxin