Detailed information of TA system TA270499

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3621775..3622197
• Replicon: chromosome
• Accession: NZ_CP117322
• Organism: Salmonella enterica subsp. enterica serovar Derby strain RM001

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3V8R754
• Locus tag: PQP82_RS17660
• Protein ID: WP_023232369.1
• Coordinates: 3621922..3622197 (+)
• Length: 92 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3621775..3622187 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PQP82_RS17630	3617044..3617541	-	498	WP_048348967.1	Saf-pilin pilus formation protein SafA	-
PQP82_RS17635	3618290..3618994	-	705	Protein_3451	integrase core domain-containing protein	-
PQP82_RS17640	3619047..3619361	+	315	WP_023892102.1	SymE family type I addiction module toxin	-
PQP82_RS17645	3619428..3619706	-	279	WP_012543321.1	hypothetical protein	-
PQP82_RS17650	3620024..3620491	-	468	WP_023232370.1	hypothetical protein	-
PQP82_RS17655	3621364..3621597	-	234	WP_124741005.1	hypothetical protein	-
-	3621775..3622187	-	413	-	-	Antitoxin
PQP82_RS17660	3621922..3622197	+	276	WP_023232369.1	SymE family type I addiction module toxin	Toxin
PQP82_RS17665	3622254..3622586	-	333	WP_001750702.1	barstar family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3609153..3644864	35711
	-	inside	Genomic island	-	-	3611974..3643378	31404

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-57)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 9883.21 Da
• Isoelectric Point: 6.6996

>T270499 WP_023232369.1 NZ_CP117322:3621922-3622197 [Salmonella enterica subsp. enterica serovar Derby]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWLAEAGFDTGASVTVKSSEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNDVVNGN

Nucleotide

• Length: 276 bp

Antitoxin

Nucleotide

• Length: 413 bp

>AT270499 NZ_CP117322:c3622187-3621775 [Salmonella enterica subsp. enterica serovar Derby]
TTCACCACATCATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGCTCTTCACGGTCACGCTCGCCCCGGTATCAAATCCCGCTT
CTGCCAGCCAGTCGCCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATGTGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCCCCCTCTCCCCGGCCAGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V8R754

Antitoxin