Detailed information of TA system TA270478

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3602783..3603205
• Replicon: chromosome
• Accession: NZ_CP117317
• Organism: Salmonella enterica subsp. enterica serovar Derby strain RM002

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3V8R754
• Locus tag: PQQ14_RS17540
• Protein ID: WP_023232369.1
• Coordinates: 3602930..3603205 (+)
• Length: 92 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3602783..3603195 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PQQ14_RS17510	3598052..3598549	-	498	WP_048348967.1	Saf-pilin pilus formation protein SafA	-
PQQ14_RS17515	3599298..3600002	-	705	Protein_3427	integrase core domain-containing protein	-
PQQ14_RS17520	3600055..3600369	+	315	WP_023892102.1	SymE family type I addiction module toxin	-
PQQ14_RS17525	3600436..3600714	-	279	WP_012543321.1	hypothetical protein	-
PQQ14_RS17530	3601032..3601499	-	468	WP_023232370.1	hypothetical protein	-
PQQ14_RS17535	3602372..3602605	-	234	WP_124741005.1	hypothetical protein	-
-	3602783..3603195	-	413	-	-	Antitoxin
PQQ14_RS17540	3602930..3603205	+	276	WP_023232369.1	SymE family type I addiction module toxin	Toxin
PQQ14_RS17545	3603262..3603594	-	333	WP_001750702.1	barstar family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3592982..3625872	32890

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-57)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 9883.21 Da
• Isoelectric Point: 6.6996

>T270478 WP_023232369.1 NZ_CP117317:3602930-3603205 [Salmonella enterica subsp. enterica serovar Derby]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWLAEAGFDTGASVTVKSSEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNDVVNGN

Nucleotide

• Length: 276 bp

Antitoxin

Nucleotide

• Length: 413 bp

>AT270478 NZ_CP117317:c3603195-3602783 [Salmonella enterica subsp. enterica serovar Derby]
TTCACCACATCATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGCTCTTCACGGTCACGCTCGCCCCGGTATCAAATCCCGCTT
CTGCCAGCCAGTCGCCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATGTGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCCCCCTCTCCCCGGCCAGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V8R754

Antitoxin