Detailed information of TA system TA270459

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 1912728..1913150
• Replicon: chromosome
• Accession: NZ_CP117312
• Organism: Salmonella enterica subsp. enterica serovar Derby strain RM003

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3V8R754
• Locus tag: PQP99_RS09105
• Protein ID: WP_023232369.1
• Coordinates: 1912728..1913003 (-)
• Length: 92 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	1912738..1913150 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PQP99_RS09100	1912339..1912671	+	333	WP_001750702.1	barstar family protein	-
PQP99_RS09105	1912728..1913003	-	276	WP_023232369.1	SymE family type I addiction module toxin	Toxin
-	1912738..1913150	+	413	-	-	Antitoxin
PQP99_RS09110	1913328..1913561	+	234	WP_124741005.1	hypothetical protein	-
PQP99_RS09115	1914434..1914901	+	468	WP_023232370.1	hypothetical protein	-
PQP99_RS09120	1915219..1915497	+	279	WP_012543321.1	hypothetical protein	-
PQP99_RS09125	1915564..1915878	-	315	WP_023892102.1	SymE family type I addiction module toxin	-
PQP99_RS09130	1915931..1916635	+	705	Protein_1786	integrase core domain-containing protein	-
PQP99_RS09135	1917384..1917881	+	498	WP_048348967.1	Saf-pilin pilus formation protein SafA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1890061..1926525	36464

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-57)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 9883.21 Da
• Isoelectric Point: 6.6996

>T270459 WP_023232369.1 NZ_CP117312:c1913003-1912728 [Salmonella enterica subsp. enterica serovar Derby]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWLAEAGFDTGASVTVKSSEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNDVVNGN

Nucleotide

• Length: 276 bp

Antitoxin

Nucleotide

• Length: 413 bp

>AT270459 NZ_CP117312:1912738-1913150 [Salmonella enterica subsp. enterica serovar Derby]
TTCACCACATCATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGCTCTTCACGGTCACGCTCGCCCCGGTATCAAATCCCGCTT
CTGCCAGCCAGTCGCCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATGTGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCCCCCTCTCCCCGGCCAGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V8R754

Antitoxin