Detailed information of TA system TA270446

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3609162..3609584
• Replicon: chromosome
• Accession: NZ_CP117307
• Organism: Salmonella enterica subsp. enterica serovar Derby strain RM004

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3V8R754
• Locus tag: PQQ01_RS17590
• Protein ID: WP_023232369.1
• Coordinates: 3609309..3609584 (+)
• Length: 92 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3609162..3609574 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PQQ01_RS17560	3604431..3604928	-	498	WP_048348967.1	Saf-pilin pilus formation protein SafA	-
PQQ01_RS17565	3605677..3606381	-	705	Protein_3437	integrase core domain-containing protein	-
PQQ01_RS17570	3606434..3606748	+	315	WP_023892102.1	SymE family type I addiction module toxin	-
PQQ01_RS17575	3606815..3607093	-	279	WP_012543321.1	hypothetical protein	-
PQQ01_RS17580	3607411..3607878	-	468	WP_023232370.1	hypothetical protein	-
PQQ01_RS17585	3608751..3608984	-	234	WP_124741005.1	hypothetical protein	-
-	3609162..3609574	-	413	-	-	Antitoxin
PQQ01_RS17590	3609309..3609584	+	276	WP_023232369.1	SymE family type I addiction module toxin	Toxin
PQQ01_RS17595	3609641..3609973	-	333	WP_001750702.1	barstar family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3596540..3632251	35711

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-57)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 9883.21 Da
• Isoelectric Point: 6.6996

>T270446 WP_023232369.1 NZ_CP117307:3609309-3609584 [Salmonella enterica subsp. enterica serovar Derby]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWLAEAGFDTGASVTVKSSEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNDVVNGN

Nucleotide

• Length: 276 bp

Antitoxin

Nucleotide

• Length: 413 bp

>AT270446 NZ_CP117307:c3609574-3609162 [Salmonella enterica subsp. enterica serovar Derby]
TTCACCACATCATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGCTCTTCACGGTCACGCTCGCCCCGGTATCAAATCCCGCTT
CTGCCAGCCAGTCGCCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATGTGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCCCCCTCTCCCCGGCCAGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V8R754

Antitoxin