Detailed information of TA system TA270415

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3601573..3601995
• Replicon: chromosome
• Accession: NZ_CP117301
• Organism: Salmonella enterica subsp. enterica serovar Derby strain RM006

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3V8R754
• Locus tag: PQP83_RS17520
• Protein ID: WP_023232369.1
• Coordinates: 3601720..3601995 (+)
• Length: 92 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3601573..3601985 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PQP83_RS17490	3596842..3597339	-	498	WP_048348967.1	Saf-pilin pilus formation protein SafA	-
PQP83_RS17495	3598088..3598792	-	705	Protein_3423	integrase core domain-containing protein	-
PQP83_RS17500	3598845..3599159	+	315	WP_023892102.1	SymE family type I addiction module toxin	-
PQP83_RS17505	3599226..3599504	-	279	WP_012543321.1	hypothetical protein	-
PQP83_RS17510	3599822..3600289	-	468	WP_023232370.1	hypothetical protein	-
PQP83_RS17515	3601162..3601395	-	234	WP_124741005.1	hypothetical protein	-
-	3601573..3601985	-	413	-	-	Antitoxin
PQP83_RS17520	3601720..3601995	+	276	WP_023232369.1	SymE family type I addiction module toxin	Toxin
PQP83_RS17525	3602052..3602384	-	333	WP_001750702.1	barstar family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3588951..3624662	35711

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-57)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 9883.21 Da
• Isoelectric Point: 6.6996

>T270415 WP_023232369.1 NZ_CP117301:3601720-3601995 [Salmonella enterica subsp. enterica serovar Derby]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWLAEAGFDTGASVTVKSSEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNDVVNGN

Nucleotide

• Length: 276 bp

Antitoxin

Nucleotide

• Length: 413 bp

>AT270415 NZ_CP117301:c3601985-3601573 [Salmonella enterica subsp. enterica serovar Derby]
TTCACCACATCATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGCTCTTCACGGTCACGCTCGCCCCGGTATCAAATCCCGCTT
CTGCCAGCCAGTCGCCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATGTGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCCCCCTCTCCCCGGCCAGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V8R754

Antitoxin