Detailed information of TA system TA270385

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/-
• Location: 1442511..1442913
• Replicon: chromosome
• Accession: NZ_CP117299
• Organism: Salmonella enterica subsp. enterica serovar Mbandaka strain SM-F22S

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A418Z3G0
• Locus tag: PH350_RS06955
• Protein ID: WP_017442176.1
• Coordinates: 1442511..1442756 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	1442606..1442913 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PH350_RS06905	1438219..1438701	+	483	WP_017442170.1	immunity 26/phosphotriesterase HocA family protein	-
PH350_RS06910	1438754..1438981	-	228	WP_017442171.1	SymE family type I addiction module toxin	-
PH350_RS06915	1439164..1439280	+	117	Protein_1338	RHS repeat-associated core domain-containing protein	-
PH350_RS06920	1439395..1439676	+	282	WP_176132412.1	hypothetical protein	-
PH350_RS06925	1439673..1440119	+	447	WP_017442172.1	hypothetical protein	-
PH350_RS06930	1440478..1440630	+	153	WP_223195354.1	hypothetical protein	-
PH350_RS06935	1440651..1440929	+	279	WP_197398372.1	hypothetical protein	-
PH350_RS06940	1440931..1441509	+	579	WP_017442174.1	hypothetical protein	-
PH350_RS06945	1441714..1442091	+	378	WP_223195355.1	HNH endonuclease	-
PH350_RS06950	1442088..1442444	+	357	WP_017442175.1	hypothetical protein	-
PH350_RS06955	1442511..1442756	-	246	WP_017442176.1	hypothetical protein	Toxin
-	1442606..1442913	+	308	-	-	Antitoxin
PH350_RS06960	1443090..1443383	+	294	WP_129369132.1	hypothetical protein	-
PH350_RS06965	1443833..1444204	+	372	WP_223195353.1	hypothetical protein	-
PH350_RS06970	1444201..1444668	+	468	WP_017442178.1	hypothetical protein	-
PH350_RS06975	1444986..1445264	+	279	WP_077907264.1	hypothetical protein	-
PH350_RS06980	1445331..1445645	-	315	WP_072103451.1	SymE family type I addiction module toxin	-
PH350_RS06985	1445698..1445856	+	159	Protein_1352	transposase	-
PH350_RS06990	1445924..1446481	-	558	Protein_1353	ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1412880..1456498	43618
	-	flank	IS/Tn	-	-	1445924..1446301	377

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 8761.95 Da
• Isoelectric Point: 4.3010

>T270385 WP_017442176.1 NZ_CP117299:c1442756-1442511 [Salmonella enterica subsp. enterica serovar Mbandaka]
MNASGASVRHINSETCMTACYSQIPSGDCQEEAGFETGRSVTVKISDGCIVLMADGNEVQKLCEQLYKAEQVVKGMWDVI
V

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 308 bp

>AT270385 NZ_CP117299:1442606-1442913 [Salmonella enterica subsp. enterica serovar Mbandaka]
CAATACACCCGTCCGAAATCTTCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGGCAGTCGCCGCTGGGG
ATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGGCGCCGGAGGCATTCATATTTGCTGA
CTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGCGAGTATGGGCGCGACATCATGG
CACCGCGCCTCCCTCTCCCCGGCCAGCACCGGGCGGTGATGAGCAACCGGCTGCCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A418Z3G0

Antitoxin