Detailed information of TA system TA270383

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 1438754..1439175
• Replicon: chromosome
• Accession: NZ_CP117299
• Organism: Salmonella enterica subsp. enterica serovar Mbandaka strain SM-F22S

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A418Z728
• Locus tag: PH350_RS06910
• Protein ID: WP_017442171.1
• Coordinates: 1438754..1438981 (-)
• Length: 76 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	1438764..1439175 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PH350_RS06875	1433920..1434126	-	207	WP_026080916.1	SymE family type I addiction module toxin	-
PH350_RS06880	1434120..1435373	+	1254	Protein_1331	RHS domain-containing protein	-
PH350_RS06885	1435376..1435663	+	288	WP_017442165.1	hypothetical protein	-
PH350_RS06890	1435732..1435866	-	135	Protein_1333	SymE family type I addiction module toxin	-
PH350_RS06895	1436292..1437260	+	969	Protein_1334	polymorphic toxin type 47 domain-containing protein	-
PH350_RS06900	1437254..1437700	+	447	WP_000935097.1	protein SciX	-
PH350_RS06905	1438219..1438701	+	483	WP_017442170.1	immunity 26/phosphotriesterase HocA family protein	-
PH350_RS06910	1438754..1438981	-	228	WP_017442171.1	SymE family type I addiction module toxin	Toxin
-	1438764..1439175	+	412	-	-	Antitoxin
PH350_RS06915	1439164..1439280	+	117	Protein_1338	RHS repeat-associated core domain-containing protein	-
PH350_RS06920	1439395..1439676	+	282	WP_176132412.1	hypothetical protein	-
PH350_RS06925	1439673..1440119	+	447	WP_017442172.1	hypothetical protein	-
PH350_RS06930	1440478..1440630	+	153	WP_223195354.1	hypothetical protein	-
PH350_RS06935	1440651..1440929	+	279	WP_197398372.1	hypothetical protein	-
PH350_RS06940	1440931..1441509	+	579	WP_017442174.1	hypothetical protein	-
PH350_RS06945	1441714..1442091	+	378	WP_223195355.1	HNH endonuclease	-
PH350_RS06950	1442088..1442444	+	357	WP_017442175.1	hypothetical protein	-
PH350_RS06955	1442511..1442756	-	246	WP_017442176.1	hypothetical protein	-
PH350_RS06960	1443090..1443383	+	294	WP_129369132.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1412880..1456498	43618

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (5-41)

Sequences

Toxin

Protein

• Length: 76 a.a.
• Molecular weight: 8375.51 Da
• Isoelectric Point: 6.2096

>T270383 WP_017442171.1 NZ_CP117299:c1438981-1438754 [Salmonella enterica subsp. enterica serovar Mbandaka]
MTTCYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHIKAGVNNVVNGD

Nucleotide

• Length: 228 bp

Antitoxin

Nucleotide

• Length: 412 bp

>AT270383 NZ_CP117299:1438764-1439175 [Salmonella enterica subsp. enterica serovar Mbandaka]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGTGGTCATGCAGGCTTTGCTGTTGATGTGG
CGGACGCTGACGCCGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAG
CTCAGGGCGAGCGAGTATGGGCGCGACATCCTGGCACTGCGCTCCCCTCTCCCCGGCCGGTGATGAGCAGCCGGCTGCCG
GGGCAGTATTTT

Structures

Toxin

• AlphaFold DB: A0A418Z728

Antitoxin