Detailed information of TA system TA270381

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 1433920..1434126
• Replicon: chromosome
• Accession: NZ_CP117299
• Organism: Salmonella enterica subsp. enterica serovar Mbandaka strain SM-F22S

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3Y1TUH5
• Locus tag: PH350_RS06875
• Protein ID: WP_026080916.1
• Coordinates: 1433920..1434126 (-)
• Length: 69 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	1433930..1434115 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PH350_RS06870	1433595..1433873	+	279	WP_017442162.1	hypothetical protein	-
PH350_RS06875	1433920..1434126	-	207	WP_026080916.1	SymE family type I addiction module toxin	Toxin
-	1433930..1434115	+	186	-	-	Antitoxin
PH350_RS06880	1434120..1435373	+	1254	Protein_1331	RHS domain-containing protein	-
PH350_RS06885	1435376..1435663	+	288	WP_017442165.1	hypothetical protein	-
PH350_RS06890	1435732..1435866	-	135	Protein_1333	SymE family type I addiction module toxin	-
PH350_RS06895	1436292..1437260	+	969	Protein_1334	polymorphic toxin type 47 domain-containing protein	-
PH350_RS06900	1437254..1437700	+	447	WP_000935097.1	protein SciX	-
PH350_RS06905	1438219..1438701	+	483	WP_017442170.1	immunity 26/phosphotriesterase HocA family protein	-
PH350_RS06910	1438754..1438981	-	228	WP_017442171.1	SymE family type I addiction module toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1412880..1456498	43618

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (1-34)

Sequences

Toxin

Protein

• Length: 69 a.a.
• Molecular weight: 7592.80 Da
• Isoelectric Point: 6.4569

>T270381 WP_026080916.1 NZ_CP117299:c1434126-1433920 [Salmonella enterica subsp. enterica serovar Mbandaka]
IPELHLKGDWLAEAGFETGTSVTVKISEGCLILIAETDEVRDLRKELYLVKKSMKHIKAGVNNVVNRD

Nucleotide

• Length: 207 bp

Antitoxin

Nucleotide

• Length: 186 bp

>AT270381 NZ_CP117299:1433930-1434115 [Salmonella enterica subsp. enterica serovar Mbandaka]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCAGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCCGAGATCTTCACGGTTACGCTCGTCCCGGTCTCAAATCCCGCCT
CGGCCAGCCAGTCGCCCTTAAGATGC

Structures

Toxin

• AlphaFold DB: A0A3Y1TUH5

Antitoxin