270154

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 322763..323554 Replicon chromosome
Accession NZ_CP117242
Organism Staphylococcus aureus strain ATCC 14458

Toxin (Protein)


Gene name - Uniprot ID A0A380E6V7
Locus tag PQQ25_RS01730 Protein ID WP_000525007.1
Coordinates 322763..323227 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag PQQ25_RS01735 Protein ID WP_000333630.1
Coordinates 323240..323554 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ25_RS01710 (318299) 318299..320230 + 1932 Protein_281 YSIRK domain-containing triacylglycerol lipase Lip2/Geh -
PQQ25_RS01715 (320324) 320324..321529 - 1206 WP_000264186.1 tyrosine-type recombinase/integrase -
PQQ25_RS01720 (321640) 321640..321819 + 180 WP_000337827.1 hypothetical protein -
PQQ25_RS01725 (321799) 321799..322731 - 933 WP_000392183.1 hypothetical protein -
PQQ25_RS01730 (322763) 322763..323227 - 465 WP_000525007.1 hypothetical protein Toxin
PQQ25_RS01735 (323240) 323240..323554 - 315 WP_000333630.1 helix-turn-helix transcriptional regulator Antitoxin
PQQ25_RS01740 (323706) 323706..323942 + 237 WP_001121116.1 helix-turn-helix transcriptional regulator -
PQQ25_RS01745 (323956) 323956..324135 + 180 WP_000438352.1 hypothetical protein -
PQQ25_RS01750 (324236) 324236..324718 - 483 WP_000394410.1 hypothetical protein -
PQQ25_RS01755 (324778) 324778..325527 + 750 WP_001148586.1 phage antirepressor KilAC domain-containing protein -
PQQ25_RS01760 (325543) 325543..325641 + 99 Protein_291 hypothetical protein -
PQQ25_RS01765 (325791) 325791..326054 + 264 WP_001124198.1 helix-turn-helix domain-containing protein -
PQQ25_RS01770 (326066) 326066..326227 + 162 WP_000066021.1 DUF1270 family protein -
PQQ25_RS01775 (326319) 326319..326579 + 261 WP_000291089.1 DUF1108 family protein -
PQQ25_RS01780 (326589) 326589..326810 + 222 WP_000815401.1 DUF2483 family protein -
PQQ25_RS01785 (326803) 326803..327591 + 789 WP_000134097.1 ATP-binding protein -
PQQ25_RS01790 (327620) 327620..328171 + 552 WP_000704705.1 single-stranded DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 320324..362645 42321
inside Prophage - geh 315773..362645 46872


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 18100.42 Da        Isoelectric Point: 4.7904

>T270154 WP_000525007.1 NZ_CP117242:c323227-322763 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAHNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEFSITFEPLRVFKLHHID

Download         Length: 465 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT270154 WP_000333630.1 NZ_CP117242:c323554-323240 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380E6V7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References