Detailed information of TA system TA270018

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 500853..501059
• Replicon: chromosome
• Accession: NZ_CP117181
• Organism: Salmonella enterica subsp. enterica serovar Mbandaka strain SM_F28S

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3Y1TUH5
• Locus tag: PQP75_RS02455
• Protein ID: WP_026080916.1
• Coordinates: 500853..501059 (+)
• Length: 69 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	500864..501049 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PQP75_RS02420	495998..496225	+	228	WP_017442171.1	SymE family type I addiction module toxin	-
PQP75_RS02425	496278..496760	-	483	WP_017442170.1	immunity 26/phosphotriesterase HocA family protein	-
PQP75_RS02430	497279..497725	-	447	WP_000935097.1	protein SciX	-
PQP75_RS02435	497719..498687	-	969	Protein_470	polymorphic toxin type 47 domain-containing protein	-
PQP75_RS02440	499113..499247	+	135	Protein_471	SymE family type I addiction module toxin	-
PQP75_RS02445	499316..499603	-	288	WP_017442165.1	hypothetical protein	-
PQP75_RS02450	499606..500859	-	1254	Protein_473	RHS domain-containing protein	-
PQP75_RS02455	500853..501059	+	207	WP_026080916.1	SymE family type I addiction module toxin	Toxin
-	500864..501049	-	186	-	-	Antitoxin
PQP75_RS02460	501106..501384	-	279	WP_017442162.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	479219..523589	44370

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (1-34)

Sequences

Toxin

Protein

• Length: 69 a.a.
• Molecular weight: 7592.80 Da
• Isoelectric Point: 6.4569

>T270018 WP_026080916.1 NZ_CP117181:500853-501059 [Salmonella enterica subsp. enterica serovar Mbandaka]
IPELHLKGDWLAEAGFETGTSVTVKISEGCLILIAETDEVRDLRKELYLVKKSMKHIKAGVNNVVNRD

Nucleotide

• Length: 207 bp

Antitoxin

Nucleotide

• Length: 186 bp

>AT270018 NZ_CP117181:c501049-500864 [Salmonella enterica subsp. enterica serovar Mbandaka]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCAGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCCGAGATCTTCACGGTTACGCTCGTCCCGGTCTCAAATCCCGCCT
CGGCCAGCCAGTCGCCCTTAAGATGC

Structures

Toxin

• AlphaFold DB: A0A3Y1TUH5

Antitoxin