Detailed information of TA system TA270016

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 495804..496225
• Replicon: chromosome
• Accession: NZ_CP117181
• Organism: Salmonella enterica subsp. enterica serovar Mbandaka strain SM_F28S

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A418Z728
• Locus tag: PQP75_RS02420
• Protein ID: WP_017442171.1
• Coordinates: 495998..496225 (+)
• Length: 76 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	495804..496215 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PQP75_RS02370	491596..491889	-	294	WP_129369132.1	hypothetical protein	-
PQP75_RS02375	492223..492468	+	246	WP_017442176.1	hypothetical protein	-
PQP75_RS02380	492535..492891	-	357	WP_017442175.1	hypothetical protein	-
PQP75_RS02385	492888..493265	-	378	WP_223195355.1	HNH endonuclease	-
PQP75_RS02390	493470..494048	-	579	WP_017442174.1	hypothetical protein	-
PQP75_RS02395	494050..494328	-	279	WP_197398372.1	hypothetical protein	-
PQP75_RS02400	494349..494501	-	153	WP_223195354.1	hypothetical protein	-
PQP75_RS02405	494860..495306	-	447	WP_017442172.1	hypothetical protein	-
PQP75_RS02410	495303..495584	-	282	WP_176132412.1	hypothetical protein	-
PQP75_RS02415	495699..495815	-	117	Protein_466	RHS repeat-associated core domain-containing protein	-
-	495804..496215	-	412	-	-	Antitoxin
PQP75_RS02420	495998..496225	+	228	WP_017442171.1	SymE family type I addiction module toxin	Toxin
PQP75_RS02425	496278..496760	-	483	WP_017442170.1	immunity 26/phosphotriesterase HocA family protein	-
PQP75_RS02430	497279..497725	-	447	WP_000935097.1	protein SciX	-
PQP75_RS02435	497719..498687	-	969	Protein_470	polymorphic toxin type 47 domain-containing protein	-
PQP75_RS02440	499113..499247	+	135	Protein_471	SymE family type I addiction module toxin	-
PQP75_RS02445	499316..499603	-	288	WP_017442165.1	hypothetical protein	-
PQP75_RS02450	499606..500859	-	1254	Protein_473	RHS domain-containing protein	-
PQP75_RS02455	500853..501059	+	207	WP_026080916.1	SymE family type I addiction module toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	479219..523589	44370

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (5-41)

Sequences

Toxin

Protein

• Length: 76 a.a.
• Molecular weight: 8375.51 Da
• Isoelectric Point: 6.2096

>T270016 WP_017442171.1 NZ_CP117181:495998-496225 [Salmonella enterica subsp. enterica serovar Mbandaka]
MTTCYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHIKAGVNNVVNGD

Nucleotide

• Length: 228 bp

Antitoxin

Nucleotide

• Length: 412 bp

>AT270016 NZ_CP117181:c496215-495804 [Salmonella enterica subsp. enterica serovar Mbandaka]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGTGGTCATGCAGGCTTTGCTGTTGATGTGG
CGGACGCTGACGCCGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAG
CTCAGGGCGAGCGAGTATGGGCGCGACATCCTGGCACTGCGCTCCCCTCTCCCCGGCCGGTGATGAGCAGCCGGCTGCCG
GGGCAGTATTTT

Structures

Toxin

• AlphaFold DB: A0A418Z728

Antitoxin