Detailed information of TA system TA270014

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/-
• Location: 492066..492468
• Replicon: chromosome
• Accession: NZ_CP117181
• Organism: Salmonella enterica subsp. enterica serovar Mbandaka strain SM_F28S

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A418Z3G0
• Locus tag: PQP75_RS02375
• Protein ID: WP_017442176.1
• Coordinates: 492223..492468 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	492066..492373 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PQP75_RS02340	488498..489055	+	558	Protein_451	ATP-binding protein	-
PQP75_RS02345	489123..489281	-	159	Protein_452	transposase	-
PQP75_RS02350	489334..489648	+	315	WP_072103451.1	SymE family type I addiction module toxin	-
PQP75_RS02355	489715..489993	-	279	WP_077907264.1	hypothetical protein	-
PQP75_RS02360	490311..490778	-	468	WP_017442178.1	hypothetical protein	-
PQP75_RS02365	490775..491146	-	372	WP_223195353.1	hypothetical protein	-
PQP75_RS02370	491596..491889	-	294	WP_129369132.1	hypothetical protein	-
-	492066..492373	-	308	-	-	Antitoxin
PQP75_RS02375	492223..492468	+	246	WP_017442176.1	hypothetical protein	Toxin
PQP75_RS02380	492535..492891	-	357	WP_017442175.1	hypothetical protein	-
PQP75_RS02385	492888..493265	-	378	WP_223195355.1	HNH endonuclease	-
PQP75_RS02390	493470..494048	-	579	WP_017442174.1	hypothetical protein	-
PQP75_RS02395	494050..494328	-	279	WP_197398372.1	hypothetical protein	-
PQP75_RS02400	494349..494501	-	153	WP_223195354.1	hypothetical protein	-
PQP75_RS02405	494860..495306	-	447	WP_017442172.1	hypothetical protein	-
PQP75_RS02410	495303..495584	-	282	WP_176132412.1	hypothetical protein	-
PQP75_RS02415	495699..495815	-	117	Protein_466	RHS repeat-associated core domain-containing protein	-
PQP75_RS02420	495998..496225	+	228	WP_017442171.1	SymE family type I addiction module toxin	-
PQP75_RS02425	496278..496760	-	483	WP_017442170.1	immunity 26/phosphotriesterase HocA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	479219..523589	44370
	-	flank	IS/Tn	-	-	488678..489055	377

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 8761.95 Da
• Isoelectric Point: 4.3010

>T270014 WP_017442176.1 NZ_CP117181:492223-492468 [Salmonella enterica subsp. enterica serovar Mbandaka]
MNASGASVRHINSETCMTACYSQIPSGDCQEEAGFETGRSVTVKISDGCIVLMADGNEVQKLCEQLYKAEQVVKGMWDVI
V

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 308 bp

>AT270014 NZ_CP117181:c492373-492066 [Salmonella enterica subsp. enterica serovar Mbandaka]
CAATACACCCGTCCGAAATCTTCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGGCAGTCGCCGCTGGGG
ATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGGCGCCGGAGGCATTCATATTTGCTGA
CTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGCGAGTATGGGCGCGACATCATGG
CACCGCGCCTCCCTCTCCCCGGCCAGCACCGGGCGGTGATGAGCAACCGGCTGCCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A418Z3G0

Antitoxin