Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 1718434..1718654 Replicon chromosome
Accession NZ_CP115183
Organism Clostridioides difficile R20291

Toxin (Protein)


Gene name CD0956.2 Uniprot ID Q183Z5
Locus tag O9S30_RS08095 Protein ID WP_003429855.1
Coordinates 1718434..1718595 (+) Length 54 a.a.

Antitoxin (RNA)


Gene name RCd10
Locus tag -
Coordinates 1718515..1718654 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O9S30_RS08065 (O9S30_08065) 1714291..1714728 + 438 WP_009888839.1 hypothetical protein -
O9S30_RS08070 (O9S30_08070) 1714721..1714897 + 177 WP_009888840.1 hypothetical protein -
O9S30_RS08075 (O9S30_08075) 1714898..1716208 + 1311 WP_009893136.1 phage tail sheath family protein -
O9S30_RS08080 (O9S30_08080) 1716225..1716695 + 471 WP_009888842.1 phage tail tube protein -
O9S30_RS08085 (O9S30_08085) 1716754..1717581 + 828 WP_009888843.1 hypothetical protein -
O9S30_RS08090 (O9S30_08090) 1717653..1718093 + 441 WP_003429853.1 phage portal protein -
O9S30_RS08095 (O9S30_08095) 1718434..1718595 + 162 WP_003429855.1 hypothetical protein Toxin
- 1718515..1718654 - 140 - - Antitoxin
O9S30_RS08100 (O9S30_08100) 1719932..1720120 + 189 WP_003429858.1 hypothetical protein -
O9S30_RS08105 (O9S30_08105) 1720239..1721105 + 867 WP_009888845.1 BRO family protein -
O9S30_RS08110 (O9S30_08110) 1721158..1721292 + 135 WP_009888846.1 hypothetical protein -
O9S30_RS08115 (O9S30_08115) 1721970..1722497 + 528 WP_009888847.1 DUF4352 domain-containing protein -
O9S30_RS08120 (O9S30_08120) 1722635..1723402 + 768 WP_009888848.1 DUF4428 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1684645..1751782 67137


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 54 a.a.        Molecular weight: 6120.42 Da        Isoelectric Point: 10.8938

>T267072 WP_003429855.1 NZ_CP115183:1718434-1718595 [Clostridioides difficile R20291]
MNNFLLNVIAGVIASLIFCLICKVFLKVKSHSTRGKSKSGWEFDFKIKFHKFK

Download         Length: 162 bp

Antitoxin


Download         Length: 140 bp

>AT267072 NZ_CP115183:c1718654-1718515 [Clostridioides difficile R20291]
AAGAAGAACTACAATCTATTTGACAGTAGAGTGAAGTTCATAATTTAAACAATTAGTAATTATTTAAATTTGTGGAACTT
GATTTTAAAATCAAATTCCCAGCCACTTTTACTCTTGCCACGAGTTGAGTGGCTTTTTAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069AVN2

Antitoxin

Download structure file

References