Detailed information of TA system TA265693

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3584587..3585008
• Replicon: chromosome
• Accession: NZ_CP113364
• Organism: Salmonella enterica subsp. enterica strain KNP01

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A418Z728
• Locus tag: OU685_RS17620
• Protein ID: WP_017442171.1
• Coordinates: 3584781..3585008 (+)
• Length: 76 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3584587..3584998 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OU685_RS17570	3580379..3580672	-	294	WP_129369132.1	hypothetical protein	-
OU685_RS17575	3581006..3581251	+	246	WP_017442176.1	hypothetical protein	-
OU685_RS17580	3581318..3581674	-	357	WP_017442175.1	hypothetical protein	-
OU685_RS17585	3581671..3582048	-	378	WP_223195355.1	HNH endonuclease	-
OU685_RS17590	3582253..3582831	-	579	WP_017442174.1	hypothetical protein	-
OU685_RS17595	3582833..3583111	-	279	WP_197398372.1	hypothetical protein	-
OU685_RS17600	3583132..3583284	-	153	WP_223195354.1	hypothetical protein	-
OU685_RS17605	3583643..3584089	-	447	WP_017442172.1	hypothetical protein	-
OU685_RS17610	3584086..3584367	-	282	WP_176132412.1	hypothetical protein	-
OU685_RS17615	3584482..3584598	-	117	Protein_3443	RHS repeat-associated core domain-containing protein	-
-	3584587..3584998	-	412	-	-	Antitoxin
OU685_RS17620	3584781..3585008	+	228	WP_017442171.1	SymE family type I addiction module toxin	Toxin
OU685_RS17625	3585061..3585543	-	483	WP_017442170.1	immunity 26/phosphotriesterase HocA family protein	-
OU685_RS17630	3586062..3586508	-	447	WP_000935097.1	protein SciX	-
OU685_RS17635	3586502..3587470	-	969	Protein_3447	polymorphic toxin type 47 domain-containing protein	-
OU685_RS17640	3587896..3588030	+	135	Protein_3448	SymE family type I addiction module toxin	-
OU685_RS17645	3588099..3588386	-	288	WP_017442165.1	hypothetical protein	-
OU685_RS17650	3588389..3589642	-	1254	Protein_3450	RHS domain-containing protein	-
OU685_RS17655	3589636..3589842	+	207	WP_026080916.1	SymE family type I addiction module toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3568002..3612372	44370

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (5-41)

Sequences

Toxin

Protein

• Length: 76 a.a.
• Molecular weight: 8375.51 Da
• Isoelectric Point: 6.2096

>T265693 WP_017442171.1 NZ_CP113364:3584781-3585008 [Salmonella enterica subsp. enterica]
MTTCYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHIKAGVNNVVNGD

Nucleotide

• Length: 228 bp

Antitoxin

Nucleotide

• Length: 412 bp

>AT265693 NZ_CP113364:c3584998-3584587 [Salmonella enterica subsp. enterica]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGTGGTCATGCAGGCTTTGCTGTTGATGTGG
CGGACGCTGACGCCGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAG
CTCAGGGCGAGCGAGTATGGGCGCGACATCCTGGCACTGCGCTCCCCTCTCCCCGGCCGGTGATGAGCAGCCGGCTGCCG
GGGCAGTATTTT

Structures

Toxin

• AlphaFold DB: A0A418Z728

Antitoxin