Detailed information of TA system TA265691

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/-
• Location: 3580849..3581251
• Replicon: chromosome
• Accession: NZ_CP113364
• Organism: Salmonella enterica subsp. enterica strain KNP01

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A418Z3G0
• Locus tag: OU685_RS17575
• Protein ID: WP_017442176.1
• Coordinates: 3581006..3581251 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3580849..3581156 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OU685_RS17540	3577281..3577838	+	558	Protein_3428	ATP-binding protein	-
OU685_RS17545	3577906..3578064	-	159	Protein_3429	transposase	-
OU685_RS17550	3578117..3578431	+	315	WP_072103451.1	SymE family type I addiction module toxin	-
OU685_RS17555	3578498..3578776	-	279	WP_077907264.1	hypothetical protein	-
OU685_RS17560	3579094..3579561	-	468	WP_017442178.1	hypothetical protein	-
OU685_RS17565	3579558..3579929	-	372	WP_223195353.1	hypothetical protein	-
OU685_RS17570	3580379..3580672	-	294	WP_129369132.1	hypothetical protein	-
-	3580849..3581156	-	308	-	-	Antitoxin
OU685_RS17575	3581006..3581251	+	246	WP_017442176.1	hypothetical protein	Toxin
OU685_RS17580	3581318..3581674	-	357	WP_017442175.1	hypothetical protein	-
OU685_RS17585	3581671..3582048	-	378	WP_223195355.1	HNH endonuclease	-
OU685_RS17590	3582253..3582831	-	579	WP_017442174.1	hypothetical protein	-
OU685_RS17595	3582833..3583111	-	279	WP_197398372.1	hypothetical protein	-
OU685_RS17600	3583132..3583284	-	153	WP_223195354.1	hypothetical protein	-
OU685_RS17605	3583643..3584089	-	447	WP_017442172.1	hypothetical protein	-
OU685_RS17610	3584086..3584367	-	282	WP_176132412.1	hypothetical protein	-
OU685_RS17615	3584482..3584598	-	117	Protein_3443	RHS repeat-associated core domain-containing protein	-
OU685_RS17620	3584781..3585008	+	228	WP_017442171.1	SymE family type I addiction module toxin	-
OU685_RS17625	3585061..3585543	-	483	WP_017442170.1	immunity 26/phosphotriesterase HocA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3568002..3612372	44370
	-	flank	IS/Tn	-	-	3577461..3577838	377

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 8761.95 Da
• Isoelectric Point: 4.3010

>T265691 WP_017442176.1 NZ_CP113364:3581006-3581251 [Salmonella enterica subsp. enterica]
MNASGASVRHINSETCMTACYSQIPSGDCQEEAGFETGRSVTVKISDGCIVLMADGNEVQKLCEQLYKAEQVVKGMWDVI
V

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 308 bp

>AT265691 NZ_CP113364:c3581156-3580849 [Salmonella enterica subsp. enterica]
CAATACACCCGTCCGAAATCTTCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGGCAGTCGCCGCTGGGG
ATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGGCGCCGGAGGCATTCATATTTGCTGA
CTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGCGAGTATGGGCGCGACATCATGG
CACCGCGCCTCCCTCTCCCCGGCCAGCACCGGGCGGTGATGAGCAACCGGCTGCCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A418Z3G0

Antitoxin