Detailed information of TA system TA264520

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3608817..3609221
• Replicon: chromosome
• Accession: NZ_CP110934
• Organism: Salmonella enterica strain CVCC 519

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: Q57SW9
• Locus tag: ORG43_RS17930
• Protein ID: WP_000994220.1
• Coordinates: 3608964..3609221 (+)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3608817..3609139 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ORG43_RS17900	3604064..3604576	-	513	WP_193581293.1	pilus assembly protein	-
ORG43_RS17905	3605326..3606030	-	705	Protein_3504	integrase core domain-containing protein	-
ORG43_RS17910	3606083..3606397	+	315	WP_001539118.1	SymE family type I addiction module toxin	-
ORG43_RS17915	3606464..3606742	-	279	WP_012664366.1	hypothetical protein	-
ORG43_RS17920	3607060..3607527	-	468	WP_001539113.1	sugar tyrosine-protein kinase	-
ORG43_RS17925	3607620..3607844	-	225	WP_001538166.1	hypothetical protein	-
-	3608817..3609139	-	323	-	-	Antitoxin
ORG43_RS17930	3608964..3609221	+	258	WP_000994220.1	SymE family type I addiction module toxin	Toxin
ORG43_RS17935	3609280..3609588	-	309	WP_001539109.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3586811..3609588	22777
	-	flank	IS/Tn	-	-	3605326..3605607	281

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9426.84 Da
• Isoelectric Point: 7.1053

>T264520 WP_000994220.1 NZ_CP110934:3608964-3609221 [Salmonella enterica]
MNASGVSVRHINSETCITTCYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYKAEQVVKGM
RDVIV

Nucleotide

• Length: 258 bp

Antitoxin

Nucleotide

• Length: 323 bp

>AT264520 NZ_CP110934:c3609139-3608817 [Salmonella enterica]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGGTGCAGGCTGGGGATTTGTGAGTAACAGGTGGTTATACAGGTTTCGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGTGAGTATGGGCGCGACATCCTGGCACTGTGCCCCCCTCTCCCCGGCCAGTGATGAGCAACCGGCTGCCGGGGCCGTAT
TTT

Structures

Toxin

• AlphaFold DB: A0A5H5BJ07

Antitoxin