Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | VII | Classification (family/domain) | TglT-TakA/AbiEii-AbiEi |
Location | 1167057..1168558 | Replicon | chromosome |
Accession | NZ_CP110619 | ||
Organism | Mycobacterium tuberculosis strain H37Rv-1 |
Toxin (Protein)
Gene name | tglT | Uniprot ID | L7N4P5 |
Locus tag | M7V54_RS05585 | Protein ID | WP_003898703.1 |
Coordinates | 1167677..1168558 (+) | Length | 294 a.a. |
Antitoxin (Protein)
Gene name | takA | Uniprot ID | L7N5C7 |
Locus tag | M7V54_RS05580 | Protein ID | WP_003405517.1 |
Coordinates | 1167057..1167680 (+) | Length | 208 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
M7V54_RS05560 | 1162553..1163380 | - | 828 | WP_003405370.1 | PE domain-containing protein | - |
M7V54_RS05565 | 1164168..1164407 | - | 240 | WP_009936438.1 | hypothetical protein | - |
M7V54_RS05570 | 1164576..1165503 | - | 928 | Protein_1097 | IS5-like element ISMt1 family transposase | - |
M7V54_RS05575 | 1165785..1166810 | - | 1026 | WP_003405514.1 | serine protease | - |
M7V54_RS05580 | 1167057..1167680 | + | 624 | WP_003405517.1 | type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein | Antitoxin |
M7V54_RS05585 | 1167677..1168558 | + | 882 | WP_003898703.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
M7V54_RS05590 | 1169428..1170675 | + | 1248 | WP_003901078.1 | IS256-like element IS1081 family transposase | - |
M7V54_RS05595 | 1171043..1172158 | - | 1116 | WP_003405582.1 | hypothetical protein | - |
M7V54_RS05600 | 1172115..1172318 | - | 204 | WP_003405585.1 | hypothetical protein | - |
M7V54_RS05605 | 1172391..1172837 | + | 447 | WP_003405595.1 | oxidation-sensing regulator MosR | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | IScluster/Tn | - | esxN | 1158922..1170675 | 11753 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 294 a.a. Molecular weight: 31958.65 Da Isoelectric Point: 6.3901
>T263986 WP_003898703.1 NZ_CP110619:1167677-1168558 [Mycobacterium tuberculosis]
VTKPYSSPPTNLRSLRDRLTQVAERQGVVFGRLQRHVAMIVVAQFAATLTDDTGAPLLLVKGGSSLELRRGIPDSRTSKD
FDTVARRDIELIHEQLADAGETGWEGFTAIFTAPEEIDVPGMPVKPRRFTAKLSYRGRAFATVPIEVSSVEAGNADQFDT
LTSDALGLVGVPAAVAVPCMTIPWQIAQKLHAVTAVLEEPKVNDRAHDLVDLQLLEGLLLDADLMPTRSACIAIFEARAQ
HPWPPRVATLPHWPLIYAGALEGLDHLELARTVDAAAQAVQRFVARIDRATKR
VTKPYSSPPTNLRSLRDRLTQVAERQGVVFGRLQRHVAMIVVAQFAATLTDDTGAPLLLVKGGSSLELRRGIPDSRTSKD
FDTVARRDIELIHEQLADAGETGWEGFTAIFTAPEEIDVPGMPVKPRRFTAKLSYRGRAFATVPIEVSSVEAGNADQFDT
LTSDALGLVGVPAAVAVPCMTIPWQIAQKLHAVTAVLEEPKVNDRAHDLVDLQLLEGLLLDADLMPTRSACIAIFEARAQ
HPWPPRVATLPHWPLIYAGALEGLDHLELARTVDAAAQAVQRFVARIDRATKR
Download Length: 882 bp
Antitoxin
Download Length: 208 a.a. Molecular weight: 22531.68 Da Isoelectric Point: 10.0518
>AT263986 WP_003405517.1 NZ_CP110619:1167057-1167680 [Mycobacterium tuberculosis]
MCAKPYLIDTIAHMAIWDRLVEVAAEQHGYVTTRDARDIGVDPVQLRLLAGRGRLERVGRGVYRVPVLPRGEHDDLAAAV
SWTLGRGVISHESALALHALADVNPSRIHLTVPRNNHPRAAGGELYRVHRRDLQAAHVTSVDGIPVTTVARTIKDCVKTG
TDPYQLRAAIERAEAEGTLRRGSAAELRAALDETTAGLRARPKRASA
MCAKPYLIDTIAHMAIWDRLVEVAAEQHGYVTTRDARDIGVDPVQLRLLAGRGRLERVGRGVYRVPVLPRGEHDDLAAAV
SWTLGRGVISHESALALHALADVNPSRIHLTVPRNNHPRAAGGELYRVHRRDLQAAHVTSVDGIPVTTVARTIKDCVKTG
TDPYQLRAAIERAEAEGTLRRGSAAELRAALDETTAGLRARPKRASA
Download Length: 624 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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