Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1564319..1564885 Replicon chromosome
Accession NC_017219
Organism Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM

Toxin (Protein)


Gene name relE Uniprot ID W6EX94
Locus tag BLIJ_RS07270 Protein ID WP_003831807.1
Coordinates 1564592..1564885 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag BLIJ_RS07265 Protein ID WP_014484914.1
Coordinates 1564319..1564588 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BLIJ_RS07240 1560069..1560763 - 695 Protein_1414 response regulator transcription factor -
BLIJ_RS07245 1560889..1561404 + 516 WP_013140733.1 hypothetical protein -
BLIJ_RS07250 1561401..1562291 + 891 WP_014484913.1 hypothetical protein -
BLIJ_RS07255 1562288..1562968 + 681 WP_003829413.1 ABC transporter ATP-binding protein -
BLIJ_RS07260 1562965..1564134 + 1170 WP_012577732.1 ABC transporter permease -
BLIJ_RS07265 1564319..1564588 + 270 WP_014484914.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BLIJ_RS07270 1564592..1564885 + 294 WP_003831807.1 type II toxin-antitoxin system YafQ family toxin Toxin
BLIJ_RS13665 1564943..1565223 + 281 Protein_1421 hypothetical protein -
BLIJ_RS07280 1565554..1566105 + 552 WP_012577735.1 RNA polymerase sigma factor -
BLIJ_RS07285 1566139..1566966 + 828 WP_012577736.1 hypothetical protein -
BLIJ_RS07290 1567098..1567724 + 627 WP_012577737.1 hypothetical protein -
BLIJ_RS07295 1567721..1568503 + 783 WP_012577738.1 hypothetical protein -
BLIJ_RS07300 1568556..1569431 + 876 WP_003829425.1 ABC transporter ATP-binding protein -
BLIJ_RS07305 1569485..1569883 + 399 WP_003829426.1 superoxide dismutase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1555334..1576692 21358


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-95)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-87)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11218.98 Da        Isoelectric Point: 9.7881

>T26378 WP_003831807.1 NC_017219:1564592-1564885 [Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM]
MLKPDYTAAFQRDIKKLKRKHTDLRPLKEVIRLVLEDTADSKEVLRRRHRAHTLTGDLNGVLECHIGNAGDWLLLWIRDD
GTAMFMRTGSHDELLGK

Download         Length: 294 bp

>T26378 NC_017219:1564592-1564885 [Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM]
ATGCTCAAACCGGATTACACAGCGGCATTCCAGCGAGATATCAAGAAACTCAAACGCAAGCACACTGATTTACGCCCGCT
GAAAGAAGTCATTCGTCTGGTTCTTGAGGACACGGCGGACTCCAAGGAAGTATTGAGGCGTAGGCATCGCGCCCACACAC
TTACCGGTGATTTAAACGGCGTATTGGAATGCCACATCGGCAATGCCGGCGACTGGCTGCTTCTATGGATTCGCGATGAT
GGTACCGCCATGTTCATGCGAACCGGCAGCCATGACGAACTGTTGGGCAAATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9902.25 Da        Isoelectric Point: 4.7872

>AT26378 WP_014484914.1 NC_017219:1564319-1564588 [Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM]
VSMASVTVRVDADTKQKAANIAEDLGLDLSSVTRAFYKQIVRERRIPLNLSYTTVPPETMEALDEAKNRLADGKPRFNSA
DEMFDSLVI

Download         Length: 270 bp

>AT26378 NC_017219:1564319-1564588 [Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM]
GTGAGCATGGCATCCGTCACAGTCCGCGTGGATGCGGACACCAAGCAGAAAGCCGCAAACATTGCCGAGGATCTCGGTCT
GGACTTGTCTTCGGTCACCCGCGCCTTCTACAAGCAGATTGTCCGGGAGAGGCGCATTCCCCTAAACCTTTCCTATACGA
CCGTGCCGCCTGAAACCATGGAGGCCCTTGACGAGGCGAAGAACAGGCTCGCCGACGGCAAACCTCGTTTCAACAGTGCC
GATGAGATGTTCGATTCGTTGGTAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W6EX94

Antitoxin

Source ID Structure

References